Sökning: "DNA-vaccine"

Visar resultat 1 - 5 av 38 avhandlingar innehållade ordet DNA-vaccine.

  1. 1. Development of novel DNA vaccine and immunotherapeutic approaches

    Författare :Maroof Hasan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Many potential DNA vaccination and immunotherapeutic strategies has been explored in both animal models and human settings in recent years. However, the failure of efficient and safe method development suggests that it is time to rethink, since more innovative approaches are needed for better control of infection and immunotherapy. LÄS MER

  3. 2. Implications of Local Puumala Hantavirus Genetics and Epidemiology for Diagnostics and Vaccine Development

    Författare :Patrik Johansson; Fredrik Elgh; Göran Bucht; Detlev Krüger; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Communicable diseases; hantavirus; Puumala virus; nephropathia epidemica; genome sequence; glycosylation; linear DNA vaccine; microarray; identification; genetic variability; Infektionssjukdomar; Infectious diseases; Infektionssjukdomar; medicinsk virologi; Medical Virology;

    Sammanfattning : Puumala viruses, a member of the Hantavirus genus in the Bunyaviridae family, are enveloped by a lipid bilayer and possesses a tripartite single stranded RNA genome with negative polarity. The hantaviruses encode four proteins: a nucleocapsid protein (N), two membrane spanning glycoproteins (GN and GC) and a RNA dependent RNA polymerase (RdRp). LÄS MER

  4. 3. Development of a therapeutic vaccine against the hepatitis C virus

    Författare :Gustaf Ahlén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HCV; NS3; DNA vaccine; electroporation;

    Sammanfattning : The hepatitis C virus (HCV) infection is a major cause of liver disease and it is estimated that 170 million people worldwide are chronically infected by HCV. There are no protective or curable vaccines available for HCV, however treatment consisting of interferon-α and ribavirin is curative in 45-75% of the chronic infected patients, depending on the viral genotype. LÄS MER

  5. 4. Vaccination against drug-resistant HIV

    Författare :Andreas Boberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV; DNA vaccine; drug-resistance;

    Sammanfattning : As the use of antiretroviral drug treatment increases worldwide, development of drug resistant HIV phenotypes is expected to increase. The frequency of drug- or multi-drug resistant virus transmitted in primary infections will consequently be more abundant. Logical vaccine targets in drug-resistant strains are reverse transcriptase and protease. LÄS MER

  7. 5. Studies of cellular pathogenesis in experimental autoimmune encephalomyelitis

    Författare :Judit Wefer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :EAE; MS; autoimmunity; DNA vaccine; antigen-specific therapies;

    Sammanfattning : In this thesis, I have studied antigen-specific therapeutic interventions of experimental autoimmune encephalomyelitis (EAE) and aimed to understand the respective roles of different cell subsets in initiation and perpetuation of disease. EAE is a commonly used animal model for the human disease Multiple Sclerosis (MS), a demyelinating disease mainly affecting young adults. LÄS MER