Sökning: "G-protein coupled receptor"

Visar resultat 11 - 15 av 172 avhandlingar innehållade orden G-protein coupled receptor.

  1. 11. Electrophysiology-based investigations of G protein-coupled receptor pharmacology

    Författare :Richard Ågren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : G protein-coupled receptors (GPCRs) constitute targets for ~34% of approved drugs. The muscarinic acetylcholine M2 receptor (M2R) activates G protein-coupled receptor inward rectifying potassium (GIRK) channels in the central nervous system and heart. Membrane potential modulates agonist potency at several GPCRs. LÄS MER

  3. 12. Aspects of proteinase-activated receptor-2: A sensor of enzymatic activity at the cell surface

    Författare :Anna-Karin Alm; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsychology; Neurology; endometrium.; coagulation; signalling; proteinase; G-protein; cell; receptor; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : Information about extracellular proteolytic activity is transduced to the cell by a transmembrane G-protein coupled receptor subfamily. These receptors are activated by proteolytic cleavage in the extracellular amino-terminal domain and are thus termed proteinase-activated receptors (PARs). LÄS MER

  4. 13. New approaches to data-driven analysis and enhanced sampling simulations of G protein-coupled receptors

    Författare :Oliver Fleetwood; Lucie Delemotte; Erik Lindahl; Ulrich Zachariae; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; GPCR; G protein-coupled receptors; Molecular Dynamics; MD; Enhanced Sampling; beta2 adrenergic receptor; beta2; Biological Physics; Biologisk fysik;

    Sammanfattning : Proteins are large biomolecules that carry out specific functions within living organisms. Understanding how proteins function is a massive scientific challenge with a wide area of applications. In particular, by controlling protein function we may develop therapies for many diseases. LÄS MER

  5. 14. Dopamine D2 receptor G protein coupling and it's regulation

    Författare :Anton Terasmaa; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Dopamine; D2 receptor; G protein; supersensitivity; 6-hydroxydopamine; [3 S]GTP-gamma-S; radioligand binding;

    Sammanfattning : Dopamine (DA) receptors belong to the superfamily of G protein coupled receptors. The D2 DA receptor is negatively coupled with adenylate cyclase via pertussis toxin sensitive (Gi/o) G proteins. LÄS MER

  7. 15. The Gene Repertoire of G protein-coupled Receptors : New Genes, Phylogeny, and Evolution

    Författare :Þóra Kristín Bjarnadóttir; Helgi B. Schiöth; Robert Fredriksson; Kurt Kristiansen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; Bioinformatics; Evolution; GPCR; Phylogeny; Farmakologi; Pharmacological research; Farmakologisk forskning;

    Sammanfattning : The superfamily of G protein-coupled receptors (GPCRs) is one of the largest protein families of mammalian genomes and can be divided into five main families; Glutamate, Rhodopsin, Adhesion, Frizzled, and Secretin. GPCRs participate in most major physiological functions, contributing to the fact that they are important targets in drug discovery. LÄS MER