Sökning: "6-hydroxydopamine"

Visar resultat 1 - 5 av 20 avhandlingar innehållade ordet 6-hydroxydopamine.

  1. 1. CELL REPLACEMENT THERAPY FOR PARKINSON’S DISEASE: The importance of neuronal subtype, cell source and connectivity for functional recovery

    Författare :Shane Grealish; Neurobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mouse behaviour; 6-hydroxydopamine; human embryonic stem cells; fetal tissue; connectivity; midbrain dopamine neuron subtype; cell transplantation; Parkinson’s disease;

    Sammanfattning : Parkinson’s disease (PD) is a neurodegenerative disorder characterised by motor deficits such as slowness in movement, difficulty in initiating movement and tremor at rest. The cause of these motor symptoms is the selective loss of mesencephalic dopaminergic (mesDA) neurons, located in the substantia nigra (SN). LÄS MER

  2. 2. Morphological and Physiological Adaptations in Cichlid Crystalline Lenses

    Författare :Marcus Schartau; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; SKF-38393; D1-agonist; optical properties 6-hydroxydopamine; optical measurements; organ culture; dopamine; teleost; lens circulation; Lens; SCH-23390; melatonin; multifocal optical system;

    Sammanfattning : Vertebrate eyes share a common ancestry as well as the basic design with a pupil, a retina and a lens. The lens is essential for perceiving the details in the world around us and ensures that a sharp image of the surroundings is focused onto the photoreceptors in the retina. LÄS MER

  3. 3. Dopamine D2 receptor G protein coupling and it´s regulation

    Författare :Anton Terasmaa; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Dopamine; D2 receptor; G protein; supersensitivity; 6-hydroxydopamine; [3 S]GTP-gamma-S; radioligand binding;

    Sammanfattning : Dopamine (DA) receptors belong to the superfamily of G protein coupled receptors. The D2 DA receptor is negatively coupled with adenylate cyclase via pertussis toxin sensitive (Gi/o) G proteins. LÄS MER

  4. 4. On the influence of glia on neurite outgrowth from dopamine neurons in the nigrostriatal system

    Författare :Malin Saga Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Dopamine; glia; astrocytes; olfactory ensheathing cells; development; ni-grostriatal; mesencephalon; Parkinson s disease; 6-hydroxydopamine;

    Sammanfattning : Interactions between glial cells and neurons are important during fetal develop-ment, in the maintenance of the normal functions in tile central nervous system (CNS), arid in response to injuries or diseases. Some of die motor disturbances in Parkinson's disease, a neurodegenerative disorder where one of the hallmarks is de-generation of dopamine (DA) neurons and concomitant depletion of DA in stria-tum, can be alleviated by intrastriatal grafting of embryonic DA tissue. LÄS MER

  5. 5. Restorative and neuroprotective treatment strategies for Parkinson’s disease: tudies on fetal dopamine cell transplants and GDNF delivery by intracerebral injections and recombinant AAV vectors

    Författare :Deniz Kirik; Neurobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adeno-associated virus; regeneration; neuroprotection; glial-cell-line-derived-neurotrophic factor; cell death; substantia nigra; dopamine; neurofysiologi; neuropsykologi; Neurologi; neurophysiology; neuropsychology; Neurology; tyrosine hydroxylase; sensorimotor behavior; transplantation; gene therapy;

    Sammanfattning : The intrastriatal 6-hydroxydopamine lesion model in rats is particularly useful in studies testing new therapeutic strategies for Parkinson’s disease. This thesis work (1) describes the characterization of the motor deficits after different types of intrastriatal lesions and identifies the four-site terminal lesion as a model of symptomatic Parkinson’s disease; (2) using the same model, provides evidence that the functional impact of the dopamine cell grafts are dependent on interactions with the host brain; (3) demonstrates that protection or restitution of normal motor function after 6-hydroxydopamine lesions can be achieved if glial cell line-derived neurotrophic factor is administered in the striatum at the time of the terminal fiber degeneration. LÄS MER