Sökning: "CNS damage"

Visar resultat 1 - 5 av 70 avhandlingar innehållade orden CNS damage.

  1. 1. Neruons; regulators of CNS inflammation

    Författare :Yawei Liu; Neuroinflammation; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunologi; serology; Immunology; T cells; inflammation; neuron; CNS; EAE MS; serologi;

    Sammanfattning : Neurons have been neglected as cells with major immune regulatory function. Here, we present novel data demonstrating that neurons are highly immune competent and play crucial role in regulation of T cell response and CNS inflammation. LÄS MER

  3. 2. Clincal Aspects of Biological Brain Damage Markers

    Författare :Johan Undén; Neurokirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomarkers markers; traumatologi; Neurology; Kirurgi; ortopedi; orthopaedics; traumatology; Surgery; intensivvård; Anestesiologi; intensive care; hematoma haematoma; Anaesthesiology; epidural; extracerebral; neurointensive care; head injury; stroke; APC APC-PCI; GFAP; NSE; S100 S-100 S100B S100BB; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; brain damage injury; serum;

    Sammanfattning : Biomarkers for organ damage and/or dysfuntion are used in almost all areas of medicine. The brain has eluded this technological development for some time. Recently, the S100B protein has been shown to be a promising marker of brain damage. However, before S100S can reach clinical reality, several problems must be solved. LÄS MER

  4. 3. Immunometabolic patterns in psychiatric disease

    Författare :Mikaela Syk; Janet Cunningham; Lisa Ekselius; Annica J. Rasmusson; Robert Fredriksson; Brenda Penninx; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Psychiatry; Human; Autoimmunity; Cytokines; Inflammation; Adiponectin; Leptin; CNS damage; NfL; Tau; GFAp; Biomarkers; Depression; Neuroticism; Bulimia nervosa; Psychiatry; Psykiatri;

    Sammanfattning : Many forms of immune system dysregulation are linked to psychiatric disorders. This thesis examines specific types of immune dysregulation in broad cohorts with psychiatric disease. The first section focuses on adipokines and other immunometabolic biomarkers and their interaction with state vs. trait symptoms. LÄS MER

  5. 4. Neurotoxicity of β-lactam antibiotics : experimental kinetic and neurophysiological studies

    Författare :Silvia E. Schliamser; Ragnar Norrby; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; benzylpenicillin; blood-brain barrier; ß-lactam antibiotics; CSF; CNS; EEG; imipenem cilastatin; FCE 22101; meningitis; neurotoxicity of; silent-second; thiopental; transport system; uraemia;

    Sammanfattning : The neurotoxic potential of intravenous administered benzylpenicillin (BPC) was studied in rabbits with intact blood-CNS barriers and rabbits with experimental E. coli meningitis. At onset of epileptogenic EEG activity or seizures, serum, CSF and brain tissue were collected for assay of BPC. LÄS MER

  7. 5. GH/IGF-I axis regulation of cardiovascular and neuronal gene expression and function

    Författare :Anna Barlind; Göteborgs universitet; []
    Nyckelord :Growth hormone; rat; hypophysectomy; vascular resistance; gene expression; place learning; Intellicage; hexarelin; CNS; hippocampus; neurogenesis; cell survival; mouse;

    Sammanfattning : Abstract Cardiovascular disease is a major cause of mortality in the Western world. Another important clinical condition is brain damage due to radiation therapy in cancer patients. This has neurological impairments presenting in the survivors. For both these conditions, it is important to develop new therapeutic strategies. LÄS MER