Sökning: "Alzheimer’s Disease"

Visar resultat 21 - 25 av 580 avhandlingar innehållade orden Alzheimer’s Disease.

1. 21. Biomarkers for Alzheimer's disease and the APOE polymorphism

   Författare :Ronald Lautner; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; Biomarkers; APOE; Cerebrospinal fluid; β-amyloid;

   Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia and cerebrospinal fluid (CSF) biomarkers reflecting the core pathology of AD are now widely used for diagnosis making, in particular β-amyloid[1-42] (Aβ42) reflecting amyloid plaque pathology, phosphorylated tau (P-tau) reflecting neurofibrillary tangle pathology and total tau (T-tau) reflecting general neurodegeneration. In addition, blood-based biomarkers for AD are in the pipeline with recent studies showing promising diagnostic potential. LÄS MER

3. 22. Polysaccharides in Alzheimer's disease and inflammation-associated amyloidosis

   Författare :Birgitta Lindahl; Uppsala universitet; []
   Nyckelord :Medical sciences; Alzheimer s disease; amyloid; heparan sulfate; keratan sulfate; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; medicinsk farmakologi; Medical Pharmacology;

   Sammanfattning : Amyloidosis is a term for diseases that share a common feature: the extracellular deposition of amyloid fibrils, that consist of a single protein prone to aggregate. Polysaccharides (glycos-aminoglycans), especially heparan sulfate, are significant components of all types of amyloid deposits. LÄS MER

4. 23. Preclinical PET imaging and therapy of Alzheimer's disease

   Författare :Silvio R. Meier; Stina Syvänen; Dag Sehlin; Greta Hultqvist; Matthias Brendel; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; amyloid-beta; positron emission tomography PET ; bispecific antibody; BACE-1; TREM2; GFAP; Molekylär medicin; Molecular Medicine; Neuroscience; Neurovetenskap;

   Sammanfattning : The main histopathological hallmarks of Alzheimer’s disease are extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles, containing tau protein. Because of misfolded and aggregated proteins, activated microglia and astroglia react with a neuroinflammatory response, which may contribute to disease progression and severity. LÄS MER

5. 24. Capturing transient peptide assemblies associated with Alzheimer's disease : Native mass spectrometry studies of amyloid-β oligomerization

   Författare :Nicklas Österlund; Astrid Gräslund; Leopold L. Ilag; Mikael Oliveberg; Sheena E. Radford; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein aggregation; amyloid-β; neurodegeneration; Alzheimer’s disease; chaperones; DnaJ; biomembranes; native mass spectrometry; Biophysics; biofysik;

   Sammanfattning : Correct folding of proteins is essential for maintaining a functional living cell. Misfolding and aggregation of proteins, where non-native intermolecular interactions form large and highly ordered amyloid aggregates with low free energy, is hence associated with multiple diseases. LÄS MER

7. 25. Neurodegenerative Biomarkers in Healthy Elderly - with special reference to the preclinical pattern of biological and cognitive markers for Alzheimer’s disease

   Författare :Erik Stomrud; Klinisk minnesforskning; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cerebral blood flow; EEG; phosphorylated tau protein; amyloid beta protein; tau protein; cerebrospinal fluid; biomarkers; preclinical Alzheimer s disease; Alzheimer s disease; MCI; dementia; SPECT; memory; cognition; early diagnosis; control groups;

   Sammanfattning : Background: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by tau and amyloid brain pathology. With the gradual degeneration of neurons, cognitive symptoms will arise and the affected individual will eventually develop AD dementia. LÄS MER