Sökning: "tau protein"

Visar resultat 1 - 5 av 77 avhandlingar innehållade orden tau protein.

  1. 1. Proximity Ligation Assay for High Performance Protein Analysis in Medicine

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Gucci Jijuan Gu; Uppsala universitet.; [2012]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein; post-translational modification; interactions; protein domain; western blotting; MARK; tau; AD; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Sammanfattning : High quality reagents are preconditions for high performance protein analyses. But despite progress in some techniques, e.g. mass spectrometry, there is still a lack of affinity-based detection techniques with enhanced precision, specificity, and sensitivity. LÄS MER

  2. 2. Proximity Ligation and Barcoding Assays Tools for analysis of proteins and protein complexes

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Di Wu; Uppsala universitet.; Uppsala universitet.; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proximity ligation assay; proximity barcoding assay; sensitive; in situ; multiplex; profiling; amyloid-beta; MARK; tau; CSF; biomarker; protein complexes; Alzheimer’s disease; amyotrophic lateral sclerosis; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Proteins are fundamental structural, enzymatic and regulatory components of cells. Analysis of proteins, such as by measuring their concentrations, characterizing their modifications, and detecting their interactions, provides insights in how biological systems work physiologically or pathologically at the molecular level. LÄS MER

  3. 3. Neurodegenerative Biomarkers in Healthy Elderly - with special reference to the preclinical pattern of biological and cognitive markers for Alzheimer’s disease

    Detta är en avhandling från Clinical Memory Research Unit, Lund University

    Författare :Erik Stomrud; Lunds universitet.; Lund University.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cerebral blood flow; EEG; phosphorylated tau protein; amyloid beta protein; tau protein; cerebrospinal fluid; biomarkers; preclinical Alzheimer s disease; Alzheimer s disease; MCI; dementia; SPECT; memory; cognition; early diagnosis; control groups;

    Sammanfattning : Background: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by tau and amyloid brain pathology. With the gradual degeneration of neurons, cognitive symptoms will arise and the affected individual will eventually develop AD dementia. LÄS MER

  4. 4. Beta-amyloid, tau-protein and cystatin C in the pathophysiology of Alzheimer´s disease

    Detta är en avhandling från Divison of Clinical Chemistry and Pharmacology, Lund University

    Författare :Maj-Linda Selenica; Lunds universitet.; Lund University.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurologi; neuropsykologi; neurofysiologi; neuropsychology; neurophysiology; Neurology; Medicine human and vertebrates ; Medicin människa och djur ; Clinical chemistry; Klinisk kemi; Kinase inhibitors; Tau protein; Cystatin C; Glycogen Synthase Kinase; Alzheimers Disease; Amyloid beta;

    Sammanfattning : Alzheimer´s Disease (AD) is a progressive neurodegenerative dementia characterized by the extracellular accumulation of the beta-amyloid (Ab) peptide into plaques and intracellular phosphorylation and accumulation of tau protein into neurofibrillary tangles (NFT). Inflammation due to astrocytic and microglial activation is one of the ongoing processes in the disease giving rise to cytokine production and oxidative stress. LÄS MER

  5. 5. Developmental Neurotoxicity of Environmental Pollutants : Effects on neuronal protein markers after neonatal exposure

    Detta är en avhandling från Uppsala : Uppsala University, Department of Organismal Biology

    Författare :Iwa Lee; Uppsala universitet.; [2013]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental neurotoxicity; Neonatal exposure; Protein markers; Environmental pollutants; Biologi med inriktning mot ekotoxikologi; Biology with specialization in Environmental Toxicology;

    Sammanfattning : This thesis focused on investigations of the developmental neurotoxic effects of bisphenol A (BPA) or perfluorohexane sulfonate (PFHxS), after a single neonatal exposure, during a critical period of the brain development in mice.BPA is a well-known industrial chemical used in the production of polymer products and PFHxS is used as an industrial additive as a surfactant. LÄS MER