Sökning: "β-amyloid"

Visar resultat 1 - 5 av 25 avhandlingar innehållade ordet β-amyloid.

1. 1. Characterization of [18F]flutemetamol binding properties : A β-amyloid PET imaging ligand

   Författare :Kerstin Heurling; Mark Lubberink; Jens Sörensen; Julie Price; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Positron emission tomography PET ; molecular imaging; amyloid; tracer validation; Radiology; Radiologi;

   Sammanfattning : The criteria for diagnosing Alzheimer’s disease (AD) have recently been revised to include the use of biomarkers for the in vivo presence of β-amyloid, one of the neuropathological hallmarks of AD. Examples of such biomarkers are positron emission tomography (PET) β-amyloid specific ligands, including [18F]flutemetamol. LÄS MER

3. 2. On the Nature of β-Amyloid at Synapses

   Författare :Isak Martinsson; Experimentell demensforskning; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; synapses; APP knockout; beta-Amyloid;

   Sammanfattning : Alzheimer’s disease is an aging related disorder of the mind, accountable for 60-80 percent of all cases of dementia. With its insidious progression and the decline of cognitive abilities, this disease is a major challenge for our society as a whole. LÄS MER

4. 3. Inflammatory cytokines and NFκB in Alzheimer’s disease

   Författare :Linda Fisher; Kerstin Iverfeldt; Illana Gozes; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; β-amyloid; interleukin-1; interleukin-6; cell-penetrating peptide; PNA; Neurochemistry; Neurokemi;

   Sammanfattning : Alzheimer’s disease is the most common form of dementia. It is a neurodegenerative disorder characterized by extracellular senile plaques and intracellular neurofibrillary tangles. The main constituent of the senile plaques is the neurotoxic β-amyloid peptide. LÄS MER

5. 4. Prediction value of genetic and neuromarkers in blood and liquor in patients with severe traumatic brain injury

   Författare :Martin Öst; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Traumatic brain injury; outcome; NFL; GFAP; tau; β-amyloid; apolipoprotein E; biochemical neuromarkers;

   Sammanfattning : Background: Severe traumatic brain injury (sTBI) is the most common cause of mortality in young adults. sTBI induces variable brain damage, invisible in Computer Tomographic scans early post-trauma. Further, neurology is difficult to evaluate in sedated patients. LÄS MER

7. 5. Biomarkers for Alzheimer's disease and the APOE polymorphism

   Författare :Ronald Lautner; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; Biomarkers; APOE; Cerebrospinal fluid; β-amyloid;

   Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia and cerebrospinal fluid (CSF) biomarkers reflecting the core pathology of AD are now widely used for diagnosis making, in particular β-amyloid[1-42] (Aβ42) reflecting amyloid plaque pathology, phosphorylated tau (P-tau) reflecting neurofibrillary tangle pathology and total tau (T-tau) reflecting general neurodegeneration. In addition, blood-based biomarkers for AD are in the pipeline with recent studies showing promising diagnostic potential. LÄS MER