Sökning: "phosphorylated tau protein"
Visar resultat 1 - 5 av 22 avhandlingar innehållade orden phosphorylated tau protein.
1. Neurodegenerative Biomarkers in Healthy Elderly - with special reference to the preclinical pattern of biological and cognitive markers for Alzheimer’s disease
Sammanfattning : Background: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by tau and amyloid brain pathology. With the gradual degeneration of neurons, cognitive symptoms will arise and the affected individual will eventually develop AD dementia. LÄS MER
2. Proximity Ligation and Barcoding Assays : Tools for analysis of proteins and protein complexes
Sammanfattning : Proteins are fundamental structural, enzymatic and regulatory components of cells. Analysis of proteins, such as by measuring their concentrations, characterizing their modifications, and detecting their interactions, provides insights in how biological systems work physiologically or pathologically at the molecular level. LÄS MER
3. Novel cerebrospinal fluid and blood tau biomarkers in Alzheimer's disease and other neurodegenerative diseases
Sammanfattning : Tau is a protein predominantly expressed in neurons in the central nervous system (CNS), where it binds microtubules (MT), playing a major role regulating their dynamics and architecture. Under pathological conditions, tau detaches from MTs, leading to neuronal dysfunction and cell death. LÄS MER
4. Ex‘PLA’ining the progression of pathological proteins in Alzheimer’s and Parkinson’s diseases : see(d)ing is believing
Sammanfattning : Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the two most common forms of neurodegenerative disorders affecting approximately 50 million people worldwide. The underlying neuropathological processes leading to AD and PD share many similarities, i.e. aberrant protein aggregation of tau and alpha-synuclein (αSyn) in the brain. LÄS MER
5. Evaluation of amyloid precursor protein and ß-amyloid as biomarkers for Alzheimer s disease
Sammanfattning : Alzheimer s disease (AD) is a neurodegenerative disorder characterised by accumulations of neurofibrillary tangles and amyloid plaques. The major components of the amyloid deposits are the ß-amyloid (Aß) peptides derived from the amyloid precursor protein (APP). LÄS MER