Sökning: "amyloid-beta"

Visar resultat 1 - 5 av 72 avhandlingar innehållade ordet amyloid-beta.

  1. 1. Electrophoretic focusing in microchannels combined with mass spectrometry Applications on amyloid beta peptides

    Detta är en avhandling från Stockholm : KTH Royal Institute of Technology

    Författare :Saara Mikkonen; KTH.; [2016]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; amyloid beta; computer simulation; electrophoresis; electrospray ionization; isoelectric focusing; isotachophoresis; MALDI; mass spectrometry; microchannel; microchip; nano-electrospray ionization; preconcentration; separation; Kemi; Chemistry;

    Sammanfattning : Analysis of low-abundance components in small samples remains a challenge within bioanalytical chemistry, and new techniques for sample pretreatments followed by sensitive and informative detection are required. In this thesis, procedures for preconcentration and separation of proteins and peptides in open microchannels fabricated on silicon microchips are presented. LÄS MER

  2. 2. Cellular responses to amyloid-beta protofibrils Focus on astrocytes, extracellular vesicles and antibody treatment

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Elisabeth Nikitidou; Uppsala universitet.; [2018]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; Amyloid-beta; Protofibrils; Astrocytes; Extracellular vesicles; Antibody; Neurons; Degradation; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Knowledge about the cellular mechanisms behind the initiation and propagation of Alzheimer’s disease (AD) is limited. Decades of research have focused on neuronal abnormalities in AD, but recently more attention has been given to the glial cells. LÄS MER

  3. 3. NMR studies of the amyloid beta-peptide

    Detta är en avhandling från Stockholm : Institutionen för biokemi och biofysik

    Författare :Jens Danielsson; Stockholms universitet.; [2007]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NMR; amyloid beta peptide; structure; metal interaction; diffusion; TECHNOLOGY Engineering physics Biophysics; TEKNIKVETENSKAP Teknisk fysik Biofysik;

    Sammanfattning : The Amyloid beta peptide (Ab) is related to Alzheimer’s disease and is suggested to be the molecular pathogenic species of the disease, probably through the neurotoxic effect of Ab oligomers. Here the results from biophysical studies of Ab and fragments thereof, are presented. LÄS MER

  4. 4. Clinical Consequences of Axonal Injury in Traumatic Brain Injury

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Sami Abu Hamdeh; Uppsala universitet.; [2018]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Traumatic brain injury; diffuse axonal injury; intracranial pressure; magnetic resonance imaging; amyloid-beta; tau; Neurokirurgi; Neurosurgery;

    Sammanfattning : Traumatic brain injury (TBI), mainly caused by road-traffic accidents and falls, is a leading cause of mortality. Survivors often display debilitating motor, sensory and cognitive symptoms, leading to reduced quality of life and a profound economic burden to society. LÄS MER

  5. 5. Beta-amyloid, tau-protein and cystatin C in the pathophysiology of Alzheimer´s disease

    Detta är en avhandling från Divison of Clinical Chemistry and Pharmacology, Lund University

    Författare :Maj-Linda Selenica; Lund University.; Lunds universitet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurologi; neuropsykologi; neurofysiologi; neuropsychology; neurophysiology; Neurology; Medicine human and vertebrates ; Medicin människa och djur ; Clinical chemistry; Klinisk kemi; Kinase inhibitors; Tau protein; Cystatin C; Glycogen Synthase Kinase; Alzheimers Disease; Amyloid beta;

    Sammanfattning : Alzheimer´s Disease (AD) is a progressive neurodegenerative dementia characterized by the extracellular accumulation of the beta-amyloid (Ab) peptide into plaques and intracellular phosphorylation and accumulation of tau protein into neurofibrillary tangles (NFT). Inflammation due to astrocytic and microglial activation is one of the ongoing processes in the disease giving rise to cytokine production and oxidative stress. LÄS MER