Sökning: "tumour control"

Visar resultat 26 - 30 av 195 avhandlingar innehållade orden tumour control.

  1. 26. Mechanistical studies on gap junctions and their role in tumour promotion : structure-activity relationships of polychlorinated biphelyls

    Författare :Yvonne Bager; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :gap junctional intercellular communication; phosphorylation; tumour promotion; alteredhepatic foci; rat liver; potency; PCBs; TCDD.Doctoral Thesis Yvonne Bager;

    Sammanfattning : Chemically induced carcinogenesis is a multi-stage process that can be divided into at least three major stages, initiation, promotion and progression. The promotion stage involves clonal expansion of genetically altered cells (i.e. initiated cells). LÄS MER

  3. 27. Cyclin E overexpression and associated events in human breast cancer

    Författare :Maria Stighall; Malmö Patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; patologisk anatomi; Patologi allmän ; pathological anatomy; General pathology; tumour growth pattern; invasion; proliferation; ID2; cyclin E; pRb; cell cycle; breast cancer;

    Sammanfattning : Unrestrained proliferation is a hallmark of cancer and genetic defects within G1/S-phase regulation and the pRb pathway occur frequently. Proliferation control can be circumvented either by excess cyclin D1 or cyclin E, alterations that can define two alternative tumour biologic pathways in breast cancer. LÄS MER

  4. 28. Phytoestrogens and prostate cancer : experimental, clinical, and epidemiological studies

    Författare :Annika Bylund; Pär Stattiin; Anders Bergh; Göran Hallmans; Swen-Olof Andersson; Umeå universitet; []
    Nyckelord :prostatic neoplasm; phytoestrogens; lignans; enterolactone; rye; 7-hydroxymataireorcinol; nude mice; TRAMP mice; nested case control study; LNCaP; Oncology; onkologi;

    Sammanfattning : Dietary factors may affect development and progression of prostate cancer. Experimental and epidemiological studies have suggested an effect of phytoestrogens on prostate cancer. Lignans are the predominant phytoestrogen in a Western diet. LÄS MER

  5. 29. High-molecular-weight insulin-like growth factor 2 : immunohistochemical, ultrastructural and biochemical findings in insulin cells under normal, diabetic, and neoplastic conditions, and its role in non-islet cell tumour hypoglycaemia

    Författare :Anders Höög; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Insulin-like growth factor-2; IGF-2; islets of Langerhans; B-granules; Diabetes Mellitus type 2; insulinoma; Goto-Kakizaki rat; haemangiopericytoma; ultrastructural immunohistochemistry; gene expression.;

    Sammanfattning : IGF-2 immunoreactive (IR) cells were identified in the normal adult pancreas of man and rat and occurred exclusively in insulin-producing cells. When frozen human pancreatic tissue was extracted and gel-size-separated, a high-molecular-weight (HMW) IGF-2 peptide could be identified. LÄS MER

  7. 30. Determination and use of radiobiological response parameters in radiation therapy optimization

    Författare :Panayiotis Mavroidis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Radiotherapy optimization; tumour control; normal tissue complications; radiobiological treatment planning; biological models; dose-response parameters;

    Sammanfattning : Optimization of radiation therapy is critically dependent on the use of patient related information. For this reason, radiobiological models describing the dependence of tumour and normal tissue responses on the irradiated volume and the dose-time-fractionation schedule should be introduced. LÄS MER