Sökning: "IGF-2"

Visar resultat 1 - 5 av 10 avhandlingar innehållade ordet IGF-2.

1. 1. High-molecular-weight insulin-like growth factor 2 : immunohistochemical, ultrastructural and biochemical findings in insulin cells under normal, diabetic, and neoplastic conditions, and its role in non-islet cell tumour hypoglycaemia

   Författare :Anders Höög; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Insulin-like growth factor-2; IGF-2; islets of Langerhans; B-granules; Diabetes Mellitus type 2; insulinoma; Goto-Kakizaki rat; haemangiopericytoma; ultrastructural immunohistochemistry; gene expression.;

   Sammanfattning : IGF-2 immunoreactive (IR) cells were identified in the normal adult pancreas of man and rat and occurred exclusively in insulin-producing cells. When frozen human pancreatic tissue was extracted and gel-size-separated, a high-molecular-weight (HMW) IGF-2 peptide could be identified. LÄS MER

3. 2. Comparatative studies on the IGF system in vertebrates : studies in rats, and in bony, cartilaginous, and jawless fish

   Författare :Katarina Drakenberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :IGF receptor; osteichthyes; chondrichthyes; cyclostomi; radioimmunoassay;

   Sammanfattning : Numerous studies have shown the importance of insulin-like growth factors (IGFs) for cellular growth, differentiation and metabolism in mammalian vertebrates. The mammalian IGF system, consists of IGF-1 and IGF-2, the IGF binding proteins (IGFBPs), and the type1 and type 2 IGF receptors. LÄS MER

4. 3. Molecular studies of the insulin-like growth factor system in the brain : focus on growth, tumorigenesis and trauma

   Författare :Ann-Christin Sandberg Nordqvist; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :insulin-like growth factors; insulin-like growth factor binding proteins; brain; mRNA; meningioma; glioma; traumatic brain injury; in situ hybridization; Northern blothybridization;

   Sammanfattning : Insulin-like growth factor (IGF) 1 and -2 are synthesized by most tissues of the body and function as autocrine or paracrine agents in a tissue-specific manner. mRNA for IGF-1 and -2, as well as the IGF-binding proteins, are synthesized locally in various regions of the brain. LÄS MER

5. 4. Neurobiological aspects on brain function in neuro-psychiatric patients and in healthy subjects

   Författare :Karin Sparring Björkstén; Carl-Gerhard Gottfries; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : The levels of insulin-like growth factor-2 (IGF-2) were assessed in lumbar cerebrospinal fluid (CSF) from children with various kinds of brain damage and from Alzheimer (AD) patients and controls. Whole CSF was separated using acid gel chromatography and the presence of insulin-like growth factor binding protein and two different kinds of free IGF-2 m the CSF was established. LÄS MER

7. 5. Regulation of CGRP expression in rat spinal motoneurons

   Författare :Fredrik Piehl; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :immunohistochemistry; in situ hybridization; motoneuron; axotomy; peptides; CGRP; trophic factor; FGF; IGF; BDNF; CNTF; GAP-43; cell culture; plasticity; mRNAregulation; regeneration;

   Sammanfattning : The normal distribution and lesion-induced changes in the expression of neuropeptides and growth-related proteins, with special reference to calcitonin gene-related peptide (CGRP),were studied in the motor system of the rat. In addition, factors that influence the expression of CGRP in motoneurons were identified. LÄS MER