Sökning: "potency"

Visar resultat 1 - 5 av 244 avhandlingar innehållade ordet potency.

  1. 1. Studies on Potency and breadth of HIV-1, HIV-2 and SIV neutralizing antibody responses

    Författare :Gülsen Özkaya Sahin; Avdelningen för medicinsk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV-1; HIV-2; SIV; envelope; neutralizing antibody; breadth; potency; IgG; IgA; complement; antibody-dependent complement-mediated inactivation; virus evolution; diversity; divergence;

    Sammanfattning : Even though the relative contribution of neutralizing antibodies (Nab) to prevent progression to AIDS during HIV-1 infection is still unclear, the induction of broadly NAb directed against HIV-1 through vaccination is considered to represent an important goal for the development of HIV-1 vaccines. Factors contributing to the induction of NAb may include the strength and duration of antigenic stimulation, the preservation of CD4+ T and B cells, the conformation of the HIV-1 envelope glycoprotein complex (Env), and the evolution of Env during infection. LÄS MER

  3. 2. Industrial work groups : the impact of job design, leader support and group processes on initiative and self-organization

    Författare :Agneta Brav; Annika Lantz; Kerstin Isaksson; Bo Ekehammar; Örebro universitet; []
    Nyckelord :SOCIAL SCIENCES; SAMHÄLLSVETENSKAP; Industrial work groups; job design; support from leader; group processes; potency; group initiative; self-organizational activities; Psychology; Psykologi; Psykologi; Psychology;

    Sammanfattning : From an organizational perspective the issue of which organizational solutions will benefit productivity, efficiency and the innovation process is central. Work groups can be an effective means. LÄS MER

  4. 3. Methods for assessing the genotoxic potency of polycyclic aromatic hydrocarbons and complex mixtures

    Författare :Michael Sjögren; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; Carcinogener; PAH; Genotoxicitet; Metoder; Blandningar; Polycykliska aromatiska föreningar;

    Sammanfattning : .... LÄS MER

  5. 4. Strategies to enhance the potency of HIV-1 DNA vaccines

    Författare :David Hallengärd; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Despite 30 years of intense research on HIV/AIDS, we have yet to arrive at a prophylactic vaccine that confers complete protection. This mission is complicated by the virus’s vast genetic variability and its ability to mask the targets for neutralizing antibodies. LÄS MER

  7. 5. Epoxides as Contact Allergens - Formation, Sensitising Potency and Structure-Activity Relationships

    Författare :Ida Belogorcev Niklasson; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :Allergic contact dermatitis; Autoxidation; Bioactivation; Cinnamic alcohol; Diglycidyl ether of bisphenol A DGEBA ; Epoxide; Epoxy resin; Local lymph node assay; Polymerisation; Peptide reactivity; Prehapten; Prohapten; Sensitisation; Skin; Structure-Activity Relationship; Thermogravimetric Analysis;

    Sammanfattning : Chemicals in our environment with which we have repeated skin contact can cause skin sensitisation (contact allergy). To trigger an immune response a compound (hapten) must be able to penetrate the skin, where it needs to be reactive enough to bind to proteins and form immunogenic complexes that are recognised as foreign. LÄS MER