Sökning: "tumour promotion"

Hittade 5 avhandlingar innehållade orden tumour promotion.

  1. 1. Liver tumour promoting effects by polychlorinated biphenyls

    Författare :Marie Haag Grönlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :tumour promotion; altered hepatic foci; rat liver; PCB; potency; TEF; interactions; antagonism; biologically based cancer growth models; TCDD;

    Sammanfattning : PCBs cause a number of toxic effects and are present in a variety of biological samples including fish, meat and diary products. Cancer is a serious toxic effect by PCBs that has been observed in animal experiments but the knowledge about PCB induced carcinogenicity is still scarce. LÄS MER

  3. 2. Mechanistical studies on gap junctions and their role in tumour promotion : structure-activity relationships of polychlorinated biphelyls

    Författare :Yvonne Bager; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :gap junctional intercellular communication; phosphorylation; tumour promotion; alteredhepatic foci; rat liver; potency; PCBs; TCDD.Doctoral Thesis Yvonne Bager;

    Sammanfattning : Chemically induced carcinogenesis is a multi-stage process that can be divided into at least three major stages, initiation, promotion and progression. The promotion stage involves clonal expansion of genetically altered cells (i.e. initiated cells). LÄS MER

  4. 3. Intracellular lipids and inflammatory activity in macrophage foam cells

    Författare :Jenny Persson; Kardiovaskulär forskning - immunitet och ateroskleros; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Cardiovascular system; lipid droplet; cytokine; inflammation; adipophilin; perilipin; atherosclerosis; Macrophage; foam cell;

    Sammanfattning : Cardiovascular disease (CVD) is characterized by lipid accumulation and inflammation in arteries. The disease starts early in life with migration of monocytes into the arterial wall where they engulf entrapped lipoproteins and become macrophage foam cell. LÄS MER

  5. 4. Inflammatory response in equine joints : studies on proinflammatory cytokines in diseased joints and chondrocyte cultures

    Författare :Cecilia Ley; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : Proinflammatory cytokines mediate inflammatory responses as well as regulate tissue metabolism. Thus, they may provide a link between inflammation and other pathologic findings seen in equine joint disease. LÄS MER

  7. 5. NF-kappaB in skin immune homeostasis and cancer development

    Författare :Maria Helena Ulvmar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The outermost part of the skin, the epidermis, is built up by cells called keratinocytes. The epidermis provides a vital barrier between the body and the outer world. It is also a target for constant physical and microbial injury. LÄS MER