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Visar resultat 1 - 5 av 1928 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Endogenous Retroviral RNA Expression in Humans

   Författare :Lijuan Hu; Jonas Blomberg; Göran Friman; Francois Mallet; Uppsala universitet; []
   Nyckelord :Microbiology; Human endogenous retrovirus HERV ; HERVE; HERVW; betaretrovirus; gammaretrovirus; RNA expression; real time PCR; endometrium; endometriosis; brain tissue; reproductive tissue; ovarian cancer; ovary; neuroblastoma cell line; Mikrobiologi;

   Sammanfattning : Human endogenous retroviruses (HERVs) constitute about 8% of the human genome. There are around 4000 pol-containing retroviral integrations in the human genome, which makes it impractical to measure each of them separately. LÄS MER

3. 2. Adipose tissue gene expression & candidate genes for obesity

   Författare :Lovisa Johansson; Diabetes - klinisk obesitasforskning; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Insulin resistance; Obesity; Adipose tissue; Adiponutrin; PNPLA; PPARGC1A; Gene expression; Case-control association study; Microarray; Genotyping; Population-based study;

   Sammanfattning : Obesity results from an interaction between genetic and environmental factors and is a growing health problem associated with development of insulin resistance, type 2 diabetes and cardiovascular disease. This thesis has focused on investigating the genetic contribution in obesity and insulin resistance by both candidate and global gene approaches with focus on the adipose tissue. LÄS MER

4. 3. Tissue Factor and CD40 Ligand : Markers for the Interplay of Coagulation and Inflammation in the Acute Coronary Syndrome

   Författare :Anders Mälarstig; Agneta Siegbahn; Lars Wallentin; Taavo Tenno; Fiona Green; Uppsala universitet; []
   Nyckelord :Molecular medicine; tissue factor; CD40 ligand; gene expression; single nucleotide polymorphism; acute coronary syndrome; myocardial infarction; coagulation; inflammation; Molekylärmedicin;

   Sammanfattning : BACKGROUND: Tissue factor (TF) is a 47 kDa transmembrane glycoprotein known as the main initiator of blood coagulation. CD40 ligand is another membrane molecule, which ligates to cell types associated with atherosclerotic plaques thereby mediating intraplaque inflammation and weakening of the fibrous cap. LÄS MER

5. 4. Human intestinal alkaline phosphatase : tissue expression and serum levels

   Författare :Ulla Domar; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Human alkaline phosphatase; intestinal alkaline phosphatase; blood; blood group; lipid; monoclonal antibody; immunohistochemistry; liver; kidney; pancreas; liver disease; inflammatory bowel disease;

   Sammanfattning : Human alkaline phosphatase (ALP) comprises four isozymes, viz liver/bone/ kidney or tissue unspecific (AP), intestinal (LAP), placental (PLAP) and germ cell or PLAP-like alkaline phosphatase, with their main expression in specific tissues as indicated by their names. The isozymes are coded by different genes, but they are closely related, with more than 50% amino acid sequence homologies. LÄS MER

7. 5. Biodegradable magnesium implants, immunomodulation, and tissue repair/regeneration

   Författare :Heithem Ben Amara; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adipose tissue; Biodegradable implants; Bone–implant interface; Bone marrow; Inflammation; Cellular mechanotransduction; Gene expression; Immunohistochemistry; Magnesium; Neovascularization; Osseointegration; Soft tissue injuries;

   Sammanfattning : The century-old paradigm of holding fractures with a metallic implant to enable bone repair, known as osteosynthesis, is still used today without alteration. Patients are increasingly being treated with metallic implants made of magnesium (Mg) that secure osteosynthesis and are reabsorbed in situ without the surgical re-entry that requires their permanent analogs. LÄS MER