Sökning: "secretory pathway"

Visar resultat 21 - 25 av 81 avhandlingar innehållade orden secretory pathway.

  1. 21. Intracellular dynamics of Alzheimer disease-related proteins

    Författare :Alexandra Selivanova; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer’s disease is a devastating neurodegenerative disorder characterized by accumulation of amyloid-β peptide and formation of amyloid plaques and aggregates of hyperphosphorylated tau protein forming neurofibrillary tangles. The amyloid-β peptide is generated through sequential processing of the amyloid precursor protein (APP) by β- and γ-secretase. LÄS MER

  3. 22. Effects of ARF1 and phospholipase D on the assembly and secretion of apoB-100 containing lipoproteins

    Författare :Lennart Asp; Göteborgs universitet; []
    Nyckelord :ApoB; ARF1; Phospholipase D; Lipoproteins; VLDL; ; Lipid droplets.;

    Sammanfattning : Hydrophobic insoluble lipids such as triglycerides and cholesterol ester are transported in spherical, water-soluble molecular complexes called lipoproteins. Lipoproteins are secreted mainly from the liver and intestine into the plasma for distribution to peripheral tissues. LÄS MER

  4. 23. Systems biology of protein synthesis and secretion in yeast

    Författare :Qi Qi; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; recombinant protein production; protein synthesis; multi-omics analysis; protein secretion; genome-scale modeling;

    Sammanfattning : Protein synthesis and secretion is a vital process to maintain cell function. As it demands numerous building blocks, cofactors and chaperones generated from metabolism and translation, the process is intertwined with metabolic and regulatory networks. LÄS MER

  5. 24. Systems Biology of Recombinant Protein Production by Fungi

    Författare :Lifang Liu; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Systems biology has emerged as a highly potent tool for studying biological processes over the last decades. However, its application to complex metabolic processes such as protein secretion is still at the infant stage. LÄS MER

  7. 25. Physiology of Saccharomyces cerevisiae Producing Recombinant Insulin in Continuous Culture

    Författare :Ali Kazemi Seresht; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; unfolded protein response; Keywords: heterologous protein production; prolonged chemostat; transcriptome; insulin analogue precursor; metabolic adaptation; URA3d; plasmid copy number; promoter truncation; high cell density cultivation; TPI1;

    Sammanfattning : The yeast Saccharomyces cerevisiae has widely been used as a host for the production of heterologous proteins. High-level production of heterologous proteins is likely to impose a metabolic burden on the host cell and can thus affect various aspects of cellular physiology. LÄS MER