Sökning: "genome-scale modeling"

Visar resultat 1 - 5 av 19 avhandlingar innehållade orden genome-scale modeling.

  1. 1. Utilization of single-cell RNA-Seq and genome-scale modeling for investigating cancer metabolism

    Författare :Johan Gustafsson; Chalmers tekniska högskola; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; genome-scale metabolic modeling; cancer; metabolism; single-cell RNA-Seq;

    Sammanfattning : Cancer remains a leading cause of death worldwide, and its dysregulated metabolism is a promising target for therapy. However, metabolism is complex to study – the metabolism of a cell involves the interplay of thousands of chemical reactions that are combined in different ways across tissues and cell types. LÄS MER

  3. 2. Systems Biology of Protein Secretion in Human Cells: Multi-omics Analysis and Modeling of the Protein Secretion Process in Human Cells and its Application

    Författare :Rasool Saghaleyni; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Erythropoietin; cancer protein secretory pathway; protein secretion modeling; HEK293; protein secretion; Integrative omics analysis; genome-scale modeling;

    Sammanfattning : Since the emergence of modern biotechnology, the production of recombinant pharmaceutical proteins has been an expanding field with high demand from industry. Pharmaceutical proteins have constituted the majority of top-selling drugs in the pharma industry during recent years. LÄS MER

  4. 3. Modeling human gut microbiota: from steady states to dynamic systems

    Författare :Hao Luo; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; dynamics.; metabolic modeling; genome-scale metabolic model; gut microbiota; cybernetic model;

    Sammanfattning : Human gut microbes are an essential part of human sub-microscopic systems and involved in many critical biological processes such as Type 2 diabetes (T2D) and osteoporosis. However, the underlying mechanisms are unclear. LÄS MER

  5. 4. Systems biology of protein synthesis and secretion in yeast

    Författare :Qi Qi; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; recombinant protein production; protein synthesis; multi-omics analysis; protein secretion; genome-scale modeling;

    Sammanfattning : Protein synthesis and secretion is a vital process to maintain cell function. As it demands numerous building blocks, cofactors and chaperones generated from metabolism and translation, the process is intertwined with metabolic and regulatory networks. LÄS MER

  7. 5. A systems biology understanding of protein constraints in the metabolism of budding yeasts

    Författare :Iván Domenzain Del Castillo Cerecer; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; gene regulation; omics analysis; enzyme capacity; metabolism; systems biology; stress adaptation; genome-scale modeling; metabolic engineering;

    Sammanfattning : Fermentation technologies, such as bread making and production of alcoholic beverages, have been crucial for development of humanity throughout history. Saccharomyces cerevisiae provides a natural platform for this, due to its capability to transform sugars into ethanol. LÄS MER