Sökning: "secretory pathway"

Visar resultat 11 - 15 av 81 avhandlingar innehållade orden secretory pathway.

  1. 11. Regulation and function of the Clara cell secretory protein

    Författare :Magnus Nord; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Lung Clara cells Uteroglobin Polychlorinated biphenyls Rat Mouse Hu-man Fetal development Glucocorticoids Cells; cultured Gene expression regulation CEBP Calcium Protein conformation Computer simulation Mutagenesis; site-directedCalcium binding pr;

    Sammanfattning : The Clara cell secretory protein (CCSP; also known as Polychlorinated Biphenyl-binding protein (PCB-BP) or Uteroglobin) is specifically produced and secreted into the distal airway lumen by the non-ciliated Clara cell. It is a low molecular weight homodimeric protein and binds certain metabolites of PCBs as well as progestins and calcium. LÄS MER

  3. 12. Characterization of secretory mechanisms in lacrimal and salivary glands

    Författare :Martin Dankis; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dry mouth; dry eyes; antidepressant; muscarinic; purinergic; salivary secretion; tear secretion; lacrimal gland; in vivo; primary culture; co-culture; acinar; myoepithelial;

    Sammanfattning : Dry mouth and dry eyes are multifactorial morbidities that can lead to a severely reduced quality of life. Approximately 20% of the population suffers from ocular or oral dryness. LÄS MER

  4. 13. Systems Biology of Protein Secretion in Human Cells: Multi-omics Analysis and Modeling of the Protein Secretion Process in Human Cells and its Application

    Författare :Rasool Saghaleyni; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Erythropoietin; cancer protein secretory pathway; protein secretion modeling; HEK293; protein secretion; Integrative omics analysis; genome-scale modeling;

    Sammanfattning : Since the emergence of modern biotechnology, the production of recombinant pharmaceutical proteins has been an expanding field with high demand from industry. Pharmaceutical proteins have constituted the majority of top-selling drugs in the pharma industry during recent years. LÄS MER

  5. 14. Protein production in the E. coli cell envelope

    Författare :Thomas Baumgarten; Jan-Willem de Gier; Dirk-Jan Scheffers; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; E. coli; protein biogenesis; recombinant proteins; membrane proteins; secretory proteins; protein displays; outer membrane vesicles; Biochemistry; biokemi;

    Sammanfattning : Proteins fulfil essential functions in every cell and malfunctioning proteins are often the cause of diseases. On the other hand, proteins like antibody fragments or hormones can be used to treat diseases. LÄS MER

  7. 15. Regulation of gut IgA induction by helper T cells

    Författare :Inta Gribonika; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mucosal immunology; secretory IgA; T regulatory cells; T follicular helper cells; Th17 cells; Peyer s patches; IgA class-switch recombination; germinal centers;

    Sammanfattning : The gut is the largest lymphoid organ in the body. Due to intense and constant exposure to the outside world, it also functions as the most important portal of entry for many pathogens. LÄS MER