Sökning: "protein secretion"

Visar resultat 1 - 5 av 505 avhandlingar innehållade orden protein secretion.

  1. 1. Recombinant subunit vaccines : protein immunogens

    Författare :Sissela Liljeqvist; KTH; []
    Nyckelord :;

    Sammanfattning : Recombinant techniques provide valuable tools for thedevelopment of modern subunit vaccines. In this thesisdifferent systems for production of recombinant subunitvaccines are presented. The strategies investigated includeprotein immunogens, live bacterial vectors and nucleicacids. LÄS MER

  2. 2. Assembly and Secretion of Atherogenic Lipoproteins

    Författare :Caroline Beck; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :; ; ; very low-density lipoprotein; apolipoprotein B100; B-cell receptor associated; microsomal triglyceride transfer protein; secretion; assembly;

    Sammanfattning : The classical dyslipidemia seen in patients with type 2 diabetes is characterized by elevated serum triglycerides (TG), low levels of high-density lipoprotein cholesterol and the appearance of small, dense low-density lipoproteins (LDL). It is now recognized that the different components of diabetic dyslipidemia are not isolated abnormalities but are closely linked to each other metabolically, and are initiated by the hepatic overproduction of large triglyceride-rich very low-density lipoproteins (VLDL1). LÄS MER

  3. 3. The Role of Protein Kinase C in the Extracellular Ca2+-regulated Secretion of Parathyroid Hormone

    Författare :Amos M. Sakwe; Lars Rask; Claes Juhlin; Uppsala universitet; []
    Nyckelord :Medical sciences; parathyroid hormone; Ca2 ; protein kinase C; calcium sensing receptor; ERK1 2; biosynthesis; secretion; MEDICIN OCH VÅRD; MEDICINE; MEDICIN;

    Sammanfattning : Parathyroid hormone (PTH) is the major physiological regulator of the extracellular Ca2+ concentration ([Ca2+]o) in the body. The secretion of this hormone is suppressed at high [Ca2+]o. LÄS MER

  4. 4. Engineering the Secretory Pathway for Recombinant Protein Secretion in Saccharomyces cerevisiae

    Författare :Jichen Bao; Chalmers University of Technology; []
    Nyckelord :NATURVETENSKAP; TEKNIK OCH TEKNOLOGIER; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; ENGINEERING AND TECHNOLOGY; MEDICAL AND HEALTH SCIENCES; endoplasmic reticulum; oxidative stress; GLO3; protein secretion; transcriptomics; drug screening; Saccharomyces cerevisiae; SEC16;

    Sammanfattning : In the past few decades there has been an increasing demand of biopharmaceutical proteins in the market. Several types of cell factories are applied to produce different pharmaceutical proteins. LÄS MER

  5. 5. Vitamin K-dependent protein S - studies of synthesis, structure and function

    Författare :Sofia Somajo; Malmö Klinisk kemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; C4b-binding protein; coagulation; microparticles; protein C; protein S; structure; tissue factor pathway inhibitor;

    Sammanfattning : This thesis is based on four projects with the overall aim to investigate vitamin K-dependent protein S functions in relation to its structure. The anticoagulant functions of protein S can be divided in three: 1) cofactor for activated protein C (APC), 2) cofactor for tissue factor pathway inhibitor (TFPI) and 3) APC and TFPI-independent anticoagulant functions. LÄS MER