Sökning: "prolonged chemostat"

Hittade 1 avhandling innehållade orden prolonged chemostat.

  1. 1. Physiology of Saccharomyces cerevisiae Producing Recombinant Insulin in Continuous Culture

    Författare :Ali Kazemi Seresht; Chalmers University of Technology; []
    Nyckelord :NATURVETENSKAP; TEKNIK OCH TEKNOLOGIER; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; ENGINEERING AND TECHNOLOGY; MEDICAL AND HEALTH SCIENCES; unfolded protein response; Keywords: heterologous protein production; prolonged chemostat; transcriptome; insulin analogue precursor; metabolic adaptation; URA3d; plasmid copy number; promoter truncation; high cell density cultivation; TPI1;

    Sammanfattning : The yeast Saccharomyces cerevisiae has widely been used as a host for the production of heterologous proteins. High-level production of heterologous proteins is likely to impose a metabolic burden on the host cell and can thus affect various aspects of cellular physiology. LÄS MER