Sökning: "multi-omics analysis"

Visar resultat 1 - 5 av 24 avhandlingar innehållade orden multi-omics analysis.

1. 1. Integrative analysis of multi-omics data reveals links between human diseases and the gut microbiota

   Författare :Peishun Li; Chalmers tekniska högskola; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; multi-omics; gut microbiota; metabolic modeling; type 2 diabetes; machine learning; osteoporosis; metabolomics;

   Sammanfattning : The gut microbiota plays a critical role in human diseases, including type 2 diabetes (T2D) and osteoporosis. Especially, probiotics have been suggested to provide potential intervention strategies for improving human health. LÄS MER

3. 2. Image-based multi-omics data integration : Exploring whole-body PET/MRI, -omics data and body composition

   Författare :Robin Visvanathar; Håkan Ahlström; Joel Kullberg; Jan Eriksson; Katrine Riklund; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Body composition; Imiomics; genomics; metabolomics; MRI; PET; insulin sensitivity; T2D;

   Sammanfattning : Advanced body composition analysis with whole-body imaging could uncover novel associations between regional tissue composition and metabolic disease. Imiomics is an automated image analysis framework that enables large-scale integration of magnetic resonance imaging (MRI) data and orthogonal technologies such as metabolomics and genomics for the detailed study of body composition. LÄS MER

4. 3. The Dark side of Obesity: Multi-omics analysis of the dysmetabolic morbidities spectrum

   Författare :Dimitra Lappa; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; systems biology; Obesity; multi-omics integration; biomarkers; gallstones; non-alcoholic fatty liver disease; GPCR receptors; metabotyping; bariatric surgery; self-organizing maps;

   Sammanfattning : Obesity is one of the most prevalent clinical conditions worldwide and is associated with a wide spectrum of dysmetabolic comorbidities. Complex cardio-metabolic disease cohorts, such as obesity cohorts are characterised by population heterogeneity, multiple underlying diseases status and different comorbidities’ treatment regiments. LÄS MER

5. 4. On metabolic networks and multi-omics integration

   Författare :Rasmus Ågren; Chalmers tekniska högskola; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; succinate; genome-scale metabolic model; metabolic engineering; systems biology; penicillin; NASH; flux balance analysis; metabolism; cancer; reconstruction;

   Sammanfattning : Cellular metabolism is a highly complex chemical system, involving thousands of interacting metabolites and reactions. The traditional approach to understanding metabolism has been that of reductionism; by isolating and carefully measuring the involved components, the goal has been to understand the whole as the sum of its parts. LÄS MER

7. 5. Multi-omics analysis of relapsed acute myeloid leukemia

   Författare :Svea Stratmann; Linda Holmfeldt; Caroline Heckman; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute myeloid leukemia AML ; relapse and resistance; next generation sequencing WGS WES ; RNA-sequencing; DNA methylation; HiRIEF LC-MS; proteogenomics; Molekylär medicin; Molecular Medicine;

   Sammanfattning : The prognosis for patients suffering from acute myeloid leukemia (AML) remains unsatisfactory and survival is often measured in months. Although the majority of patients achieve complete remission after aggressive treatment, most of them relapse within a few years. LÄS MER