Sökning: "Phospholipase D"

Visar resultat 1 - 5 av 31 avhandlingar innehållade orden Phospholipase D.

  1. 1. Membrane lipids and their transfer proteins in β-cells

    Författare :Beichen Xie; Olof Idevall-Hagren; Anders Tengholm; Jen Liou; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ca2 ; PKC; E-Syt1; TMEM24; ER-PM contact; PI 4; 5 P2; phosphoinositides; β-cell; insulin; optogenetics; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Sammanfattning : Insulin secretion from β-cells is essential for glucose homeostasis and is often dysregulated in diabetes. Intracellular Ca2+ and membrane lipids cooperate to control insulin secretion with high spatial and temporal precision. LÄS MER

  2. 2. Role of Inducible Nitric Oxide Synthase and Melatonin in Regulation of β-cell Sensitivity to Cytokines

    Författare :Annika K. Andersson; Stellan Sandler; Nils Welsh; Décio L. Eizirik; Nils Billestrup; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; β-cell; Cyclooxygenase; Cytokine; Diabetes; IFN-γ; IL-1β; iNOS; Insulin; Melatonin; Nitric oxide; Pancreatic islets; Phospholipase D; Prostaglandin E2; Streptozotocin; Cellbiologi; Cell biology; Cellbiologi;

    Sammanfattning : The mechanisms of β-cell destruction leading to type 1 diabetes are complex and not yet fully understood, but infiltration of the islets of Langerhans by autoreactive immune cells is believed to be important. Activated macrophages and T-cells may then secrete cytokines and free radicals, which could selectively damage the β-cells. LÄS MER

  3. 3. Neutrophil phagocytosis and secretion : The role of calcium and the cytoskeleton

    Författare :Lena Serrander; Joel D. Ernst; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Neutrophils assure rapid removal of bacteria by a variety of processes. They crawl out of the vessels, phagocytose the bacteria and kill them by secretion of bactericidal substances and production of oxidative metabolites. LÄS MER

  4. 4. Effects of ARF1 and phospholipase D on the assembly and secretion of apoB-100 containing lipoproteins

    Författare :Lennart Asp; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :; ApoB; ARF1; Phospholipase D; Lipoproteins; VLDL; Lipid droplets.;

    Sammanfattning : Hydrophobic insoluble lipids such as triglycerides and cholesterol ester are transported in spherical, water-soluble molecular complexes called lipoproteins. Lipoproteins are secreted mainly from the liver and intestine into the plasma for distribution to peripheral tissues. LÄS MER

  5. 5. Studies on the assembly of cytosolic lipid droplets. Importance of Phospholipase D and ADRP in the process

    Författare :Denis Marchesan; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :Lipid droplets; triglycerides; caveolin; Phospholipase D PLD ; adipocyte differentiation related protein ADRP ; EGCG;

    Sammanfattning : The storage of triglycerides in cells such as adipocytes, liver or muscle cells is of great physiological importance, having implications for our most important metabolic diseases such as obesity, the metabolic syndrome and type II diabetes. A common denominator in these diseases is the insulin resistance, which is also highly related to the production of atherogenic lipoproteins and the development of atherosclerosis and consequently cardio-vascular diseases. LÄS MER