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Visar resultat 1 - 5 av 9 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Exploring Palladium-Mediated 11C/12C-Carbonylation Reactions : PET Tracer Development Targeting the Vesicular Acetylcholine Transporter

    Författare :Sara Roslin; Mats Larhed; Gunnar Antoni; Jonas Eriksson; Luke Odell; Victor Pike; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Carbonylation; palladium; carbon-11; radiochemistry; positron emission tomography; vesicular acetylcholine transporter; vesamicol; alkyl halide; oxidative carbonylation; acylamidine; oxadiazole; heterocycle; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : The work presented herein describes the utilization and exploration of palladium-mediated incorporations of carbon monoxide and/or [11C]carbon monoxide into compounds and structural motifs with biological relevance.The first part of the thesis describes the design, synthesis and 11C-labeling of prospective PET tracers for the vesicular acetylcholine transporter (VAChT), a target affected in several neurodegenerative diseases. LÄS MER

  3. 2. Palladium-Catalyzed Carbonylation and Arylation Reactions

    Författare :Jonas Sävmarker; Mats Larhed; Gary Molander; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; palladium; carbonylation; styrene; amidine; aryl ketones; aryl sulfinates; ESI-MS; aryltrifluoroborates; Organic Pharmaceutical Chemistry; Organisk farmaceutisk kemi;

    Sammanfattning : Palladium-catalyzed reactions have found widespread use in contemporary organic chemistry due to their impressive range of functional group tolerance and high chemo- and regioselectivity. The pioneering contributions to the development of the Pd-catalyzed C-C bond forming cross-coupling reaction were rewarded with the Nobel Prize in Chemistry in 2010. LÄS MER

  4. 3. Advances in Stereoselective Palladium(ΙΙ)-Catalyzed Oxidative Transformations of Allenes

    Författare :Daniels Posevins; Jan-Erling Bäckvall; Troels Skrydstrup; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Synthesis; Palladium Catalysis; Allenes; Biomimetic; Carbocyclization; Borylation; Carbonylation; Oxidation; Heterogeneous; organisk kemi; Organic Chemistry;

    Sammanfattning : Palladium(ΙΙ)-catalyzed carbon-carbon and carbon-heteroatom bond formation via selective C-H bond oxidation constitutes a step-economical and versatile approach towards complex target molecules. This thesis has been focused on the development of new selective palladium(ΙΙ)-catalyzed transformations of allenes under oxidative conditions catalyzed by either homogenous or heterogeneous palladium(ΙΙ) catalysts. LÄS MER

  5. 4. Novel Metal-Mediated Organic Transformations : Focusing on Microwave Acceleration and the Oxidative Heck Reaction

    Författare :Per-Anders Enquist; Mats Larhed; Anders Hallberg; Troels Skrydstrup; Uppsala universitet; []
    Nyckelord :Organic chemistry; palladium II ; oxidative Heck reaction; high-throughput-chemistry; microwave acceleration; dicobalt octacarbonyl; in situ carbonylation; urea; diaryl ketones; ESI-MS; Organisk kemi;

    Sammanfattning : Transition metals have played an important role in synthetic organic chemistry for more than a century, and offer catalytic transformations that would have been impossible with classical chemistry. One of the most useful and versatile of the transition metals is palladium, which over the years has catalyzed many important carbon-carbon forming reactions. LÄS MER

  7. 5. Protein Damage Control during Embryonic Stem Cell Differentiation: Role of the Proteasome

    Författare :Malin Hernebring; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Embryonic Stem Cells; Proteasome; Protein Carbonylation; Advanced Glycation End products; Cell Differentiation; Oxidative stress; Aging; RNAi;

    Sammanfattning : During the lifespan of organisms ranging from yeast to humans, there is an accumulation of macromolecular damage. However, these organisms produce youthful progeny with low damage levels. This thesis focuses on how this is accomplished. LÄS MER