Sökning: "alkyl halide"
Hittade 4 avhandlingar innehållade orden alkyl halide.
1. Exploring Palladium-Mediated 11C/12C-Carbonylation Reactions : PET Tracer Development Targeting the Vesicular Acetylcholine Transporter
Sammanfattning : The work presented herein describes the utilization and exploration of palladium-mediated incorporations of carbon monoxide and/or [11C]carbon monoxide into compounds and structural motifs with biological relevance.The first part of the thesis describes the design, synthesis and 11C-labeling of prospective PET tracers for the vesicular acetylcholine transporter (VAChT), a target affected in several neurodegenerative diseases. LÄS MER
2. Unsymmetric PCN Pincer Palladium and Nickel Complexes : Synthesis, Characterization and Reactivity
Sammanfattning : New palladium and nickel complexes based on unsymmetric PCN pincer ligands have been synthesized and fully characterized using different techniques. The substituents on the nitrogen side arm of the ligand have great influence on the cyclometallation and the reactivity of the new complexes particularly in case of nickel. LÄS MER
3. Iron catalyzed C-C coupling reactions - mechanistic investigations
Sammanfattning : The mechanism of the iron catalyzed cross coupling of aryl electrophiles with alkyl Grignard reagents was studied. The reaction proceeds via a rate-limiting oxidative addition of the aryl halide to an Fe(I) complex generated in situ. A transmetalation from an aryl Grignard reagent occurs either before or after the oxidative addition. LÄS MER
4. Functional Cyclic Carbonate Monomers and Polycarbonates : Synthesis and Biomaterials Applications
Sammanfattning : The present work describes a selection of strategies for the synthesis of functional aliphatic polycarbonates. Using an end-group functionalization strategy, a series of DNA-binding cationic poly(trimethylene carbonate)s was synthesized for application as vectors for non-viral gene delivery. LÄS MER