Sökning: "ESI-MS"

Visar resultat 1 - 5 av 81 avhandlingar innehållade ordet ESI-MS.

  1. 1. Interfacing HPLC with MALDI- and ESI-MS for Automated High Sensitivity Analysis of Proteins and Peptides

    Författare :Tasso Miliotis; Lund Institutionen för kliniska vetenskaper; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; automated; phosphorylation; ZAP-70; peptides; proteins; comprehensive; multidimensional; two-dimensional; piezoelectric; microdispenser; flow-through; ESI-MS MS; Capillary HPLC; MALDI-TOF MS; Analytical chemistry; Analytisk kemi;

    Sammanfattning : The research described in this thesis has an interdisciplinary approach dealing with chemical, biological, and technical issues. One objective was to interface miniaturized liquid chromatography (LC) to mass spectrometry, i.e. MALDI-TOF MS and ESI-MS, in an unattended mode for high sensitivity determination of proteins and peptides. LÄS MER

  2. 2. Methods for structural studies of an antibody, screening metabolites in rat urine and analysis of spent cell cultivation media using LC/ESI-MS and chemometrics

    Författare :Leila Zamani; Sven P. Jacobsson; Jonas Bergqvist; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Screening; Fingerprinting; metabolomics; Protein drugs; Mammalian Cell lines; LC ESI-MS; chemometrics; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

    Sammanfattning : This thesis describes bioanalytical methods for generating fingerprints of biological systems for extracting relevant information with (protein) drugs in focus. Similarities and differences between samples can reveal the hidden relevant information, which can be used to optimize the production and facilitate the quality control of such protein drugs during their development and manufacture. LÄS MER

  3. 3. Tuning the polylactide hydrolysis rate without introducing new migrants

    Författare :Sofia Regnell Andersson; Minna Hakkarainen; Karin Jacobson; Ulrika Edlund; KTH; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES; polylactide; sterocomplex; plasticizer; degradation; degradation products; ESI-MS; Biochemistry; Biokemi; Polymer chemistry; Polymerkemi;

    Sammanfattning : The possibility to control and tune the hydrolytic degradation rate of polylactide without introducing any new degradation products was investigated by subjecting polylactide with cyclic or linear oligolactic acid additives, and a stereocomplex between the L- and D-enantiomers of polylactide to hydrolytic degradation at 37 and 60 °C for up to 39 weeks. The degradation was monitored by measuring mass loss, molar mass changes, water uptake, changes of surface structure, crystallinity and thermal properties. LÄS MER

  4. 4. Palladium(II)-Catalyzed Coupling Reactions

    Författare :Jonas Lindh; Mats Larhed; Matthew S. Sigman; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Palladium II ; oxidative Heck reactions; Microwaves; Styrenes; Aryl ketones; Continuous flow; ESI-MS; Pharmaceutical chemistry; Farmaceutisk kemi; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : Sustainable chemical processes are becoming increasingly important in all fields of synthetic chemistry. Catalysis can play an important role in developing environmentally benign chemical processes, and transition metals have an important role to play in the area of green chemistry. LÄS MER

  5. 5. Characterisation of the Substituent Distribution in Starch and Cellulose Derivatives

    Författare :Sara Richardson; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Analytisk kemi; Cationic amylopectin; Hydroxypropyl amylopectin; Ethyl hydroxyethyl cellulose; Substituent distribution; Enzymic degradation; HPAEC-PAD; MALDI-TOF-MS; ESI-MS; Kemi; Analytical chemistry;

    Sammanfattning : Starch and cellulose can be chemically modified to produce derivatives with specific properties. Knowledge of correlations between the modification reaction, substituent distribution and properties is important in order to design modification processes so as to produce derivatives with the desired properties. LÄS MER