Sökning: "Luke Odell"
Visar resultat 1 - 5 av 9 avhandlingar innehållade orden Luke Odell.
1. Palladium(0)-Catalyzed Synthesis of Spirocycles and Supercritical Chemistry using a Resistively Heated Flow Reactor
Sammanfattning : This doctoral thesis focusses on an effective and selective approach to the synthesis of spirocycles using palladium(0)-catalyzed Mizoroki-Heck reactions. In addition, selective and efficient chemistry was highlighted by the design and evaluation of a novel resistively heated system for continuous flow (CF) synthesis for high-temperature and high-pressure applications. LÄS MER
2. Development of HIV-1 Protease Inhibitors and Palladium-Catalyzed Synthesis of Aryl Ketones and N-Allylbenzamides
Sammanfattning : The use of palladium-catalyzed reactions to introduce new carbon-carbon bonds is a fundamental synthetic strategy that has been widely embraced due to its high chemo- and regioselectivity and functional group tolerance. In this context, Pd(0)-catalyzed aminocarbonylations using Mo(CO)6 instead of toxic and gaseous CO and with allylamine as the nucleophile were investigated. LÄS MER
3. Hydroarylation of Fullerene C60 Using Arylboronic Acids via Rhodium Catalysis : Improving the Outcomes and Simplifying the Conditions
Sammanfattning : Hydroarylation with arylboronic acids is one of the functionalization methods for synthesis of modified fullerenes. In this work, we provide a fast and reproducible one-phase method for hydroarylation of fullerene using boronic acids and an analytical HPLC method that efficiently separates unreacted C60 and product from a hydroarylation reaction mixture as well as a fulleropyrrolidine reaction mixture. LÄS MER
4. A Chemical Approach Toward the Therapeutic Optimization of Cytotoxic Bioconjugates
Sammanfattning : The delivery of cytotoxicity to specific cells was recognized to be the key to the effective, chemical treatment of infectious and neoplastic diseases well over a century ago. In the context of oncology, the primary therapeutic challenge is the distinction between healthy and pathological cells despite their pronounced pheno- and genotypic similarity. LÄS MER
5. Development of Palladium-Promoted 11C/12C-Carbonylations and Radiosynthesis of Amyloid PET Ligands
Sammanfattning : In the first part of this thesis, palladium(0)-catalyzed and -mediated carbonylations are discussed. Paper I describes a new method for the safe, efficient use of a solid carbon monoxide source in the synthesis of primary and secondary benzamides. LÄS MER