Sökning: "Jan-Erling Bäckvall"
Visar resultat 1 - 5 av 41 avhandlingar innehållade orden Jan-Erling Bäckvall.
1. Palladium(II)-Catalyzed Oxidative Carbocyclization/Functionalization of Allenynes
Sammanfattning : The selective formation of carbon-carbon bonds constitutes a key transformation in organic synthesis with useful applications in pharmaceutical or material industry. A particularly versatile tool for carbon-carbon as well as carbon-heteroatom bond formation is palladium catalysis, which allows for mild and selective routes even towards complex structures. LÄS MER
2. Palladium(II)-Catalyzed Oxidative Carbocyclization/Functionalization of Allenynes
Sammanfattning : Palladium catalysis has emerged as an outstanding tool in synthetic organic chemistry for the mild and selective formation of carbon-carbon and carbon-heteroatom bonds. This thesis has been directed towards the extension of palladium(II)-catalyzed carbocyclization chemistry under oxidative conditions. LÄS MER
3. Synthetic Transformations via Metal- and Enzyme-Catalyzed Dynamic Kinetic Resolution
Sammanfattning : This thesis deals with the preparation of a new half-sandwich type ruthenium(II)- catalyst for racemization of optically active secondary alcohols and the development of a highly efficient method in combination with lipases such as Candida antarctica lipase B and Pseudomonas cepacia lipase for dynamic kinetic resolution of various functionalized alcohols under mild reaction conditions.It was shown that the RuCl(CO)2(η5-C5Ph5) complex can racemize optically active aliphatic and aromatic secondary alcohols at room temperature in rather short times. LÄS MER
4. Enantioselective Synthesis of Sec-Alcohol Derivatives and Diols via Combined Ruthenium and Enzyme Catalysis
Sammanfattning : The first part of this thesis describes the synthesis of enantiopure secondary alcohol derivatives. These syntheses are carried out via the combination of an enzyme as a resolution catalyst and a ruthenium catalyst as a racemization catalyst, in what is called dynamic kinetic resolution (DKR). LÄS MER
5. Studies of Biomimtic Oxidations and Racemizations
Sammanfattning : This thesis deals with studies of ruthenium-catalyzed hydrogen transfer reactions for oxidations and racemization.Through optimisation of the substrate-selective redox catalyst, the electron and proton transfer mediator (a benzoquinone derivative), and the oxygen-activating metal macrocycle a highly efficient biomimetic oxidation of secondary alcohols was obtained. LÄS MER