Sökning: "oligodendrocyte progenitor cells"
Visar resultat 1 - 5 av 16 avhandlingar innehållade orden oligodendrocyte progenitor cells.
1. Oligodendrocyte pathology following Traumatic Brain Injury : Experimental and clinical studies
Sammanfattning : Traumatic brain injury (TBI) caused by traffic and fall accidents, sports-related injuries and violence commonly results in life-changing disabilities. Cognitive impairments following TBI may be due to disruption of axons, stretched by the acceleration/deceleration forces of the initial impact, and their surrounding myelin in neuronal networks. LÄS MER
2. Translational research of the quaking gene : Focusing on the conjunction between development and disease
Sammanfattning : Quaking (QKI) is an RNA binding protein involved in the post-transcriptional regulation of gene expression. Originally identified as the cause of hypomyelination in a mouse mutant, it has since been consistently implicated in a wide range of neurological diseases. LÄS MER
3. Directing stem cells and progenitors towards neuronal differentiation - implications for experimental therapies for Parkinson's disease
Sammanfattning : The insight that stem- and progenitor-cells contribute to replacement of nerve cells in the adult central nervous system is the basis of modern therapies for structural brain repair. Their goal is to protect, support and stimulate endogenous stem cells in areas affected by disease and to replace lost cells by transplanting in vitro generated, tailored nerve cells. LÄS MER
4. Cell states along oligodendrocyte development and disease
Sammanfattning : The brain, one of the most complex organs in the body, where an immense diversity of cell states emerges from simple structure, where function arises from sets of regulatory principles and pattern persist where individual cells do not. Revealing the regulatory underpinnings of the brain, from unspecified cell states to diversity, is paramount for achieving a thorough understanding of the development process and generating insight into the disease states of the brain. LÄS MER
5. Cellular Origin and Development of Glioma
Sammanfattning : Gliomas are the most common primary tumors of the central nervous system believed to arise from glial cells. Invasive growth and inherent propensity for malignant progression make gliomas incurable despite extensive treatment. LÄS MER