Sökning: "histidine-rich glycoprotein"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden histidine-rich glycoprotein.

  1. 1. The Histidine-rich Glycoprotein in Reproduction

    Författare :Karin E Lindgren; Inger Sundström-Poromaa; Helena Åkerud; Eva Wiberg-Itzel; Lalit Kumar Parameswaran Grace; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Angiogenesis; embryo culture medium; embryogenesis; embryonic secretome; endometrium; histidine-rich glycoprotein; human embryo development; human embryo implantation; human endometrial endothelial cells; in vitro fertilisation; infertility; male infertility; proximity extension assay; recurrent miscarriage; single nucleotide polymorphism; sperm quality; time-lapse technique; vascular endothelial growth factor;

    Sammanfattning : Infertility affects 15% of reproductive-aged couples. The milieu surrounding the growing embryo is of outmost importance, and should be optimised during in vitro fertilisation (IVF). Many biological processes, such as angiogenesis, coagulation, and immune processes need to be well regulated for a pregnancy to occur and progress normally. LÄS MER


    Författare :Victoria Rydengård; Lund Dermatologi och venereologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dermatologi; venereologi; venereology; Dermatology; histidine-rich glycoprotein; heparin-binding; zinc; low pH; Medicine human and vertebrates ; Medicin människa och djur ; innate immunity; antimicrobial;

    Sammanfattning : In an environment full of potential pathogens it is of importance for organisms to mount a fast and effective defence. Antimicrobial peptides are ancient and integral effector molecules of the innate immune system. They are found in all kinds of species from bacteria to plants and animals, indicating their importance during evolution. LÄS MER

  3. 3. The Role of Histidine-rich Glycoprotein in Angiogenesis and Tumor Growth

    Författare :Åsa Thulin; Anna-Karin Olsson; Pirjo Laakkonen; Uppsala universitet; []
    Nyckelord :Histidine-rich glycoprotein; HRG HRGP HPRG; angiogenesis inhibitor; cancer; VEGF; platelets; MEDICINE; MEDICIN; Medicin; Medicine;

    Sammanfattning : Histidine-rich glycoprotein (HRG) is a heparin-binding plasma protein modulating immune, hemostatic and vascular functions. I have studied the antiangiogenic functions of HRG in vitro and in vivo in order to understand the molecular mechanisms of action of HRG as an angiogenesis inhibitor. LÄS MER

  4. 4. Molecular Mechanisms of Action of Histidine-rich Glycoprotein in Angiogenesis Inhibition

    Författare :Chunsik Lee; Lena Claesson-Welsh; Jan Palmblad; Uppsala universitet; []
    Nyckelord :Cell and molecular biology; anti-angiogenesis; angiogenesis inhibitor; endothelial cell; histidine-rich glycoprotein; focal adhesion; tumor-associated macrophages; VEGF; MMP; Cell- och molekylärbiologi;

    Sammanfattning : Angiogenesis, de novo synthesis of blood vessels from the pre-existing vasculature, is required both during embryonic development and in pathophysiological conditions. In particular, tumor growth needs new capillary vessels in order to both deliver oxygen and nutrients and to remove toxin and metabolites. LÄS MER

  5. 5. Investigating histidine-rich glycoprotein and T cell-specific adaptor as potential biomarkers and therapeutic targets

    Författare :Tor Persson Skare; Lena Claesson-Welsh; Mats Hellström; Elin Sjöberg; Jonas Fuxe; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Histidine-rich glycoprotein; T cell-specifik adaptor; Lymphoma; Glioblastoma; Vascular permeability;

    Sammanfattning : The endothelial cell (EC), the most important cell type in blood vessels, lines the vessel wall and provides vessel integrity. EC function is tightly regulated, and its dysregulation is a key element in many diseases including cardiovascular disease, cancer and several diseases of the eye. LÄS MER