Sökning: "homology-directed repair"

Hittade 3 avhandlingar innehållade orden homology-directed repair.

  1. 1. Cellular Origin and Development of Glioma

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Nanna Lindberg; Uppsala universitet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioma; brain tumor; PDGF; RCAS TV-A; cell of origin; glial cell; oligodendrocyte progenitor cell; DNA repair; homology-directed repair; RAD51; angiogenesis; histidine-rich glycoprotein; MEDICINE Morphology; cell biology; pathology; MEDICIN Morfologi; cellbiologi; patologi; Molecular Medicine; molekylär medicin genetik och patologi ;

    Sammanfattning : Gliomas are the most common primary tumors of the central nervous system believed to arise from glial cells. Invasive growth and inherent propensity for malignant progression make gliomas incurable despite extensive treatment. LÄS MER

  2. 2. DNA repair by HDR in experimental tumorigenesis

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Oncology-Pathology

    Författare :Ulrica Westermark; Karolinska Institutet.; Karolinska Institutet.; [2008]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The aim of this thesis was to further understand how defects in the homology-directed repair (HDR) pathway affect tumor formation and development. To study proteins involved in HDR is challenging since most of its members are required for cell viability. LÄS MER

  3. 3. Cell cycle regulation in cancer: A noncoding perspective

    Detta är en avhandling från Göteborgs universitet

    Författare :Mohamad Ali; Göteborgs universitet.; Gothenburg University.; [2019]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Long Noncoding RNA; lncRNA; Cell cycle; S phase; Mitosis; Checkpoint; Cancer; SCAT7; LY6K-AS;

    Sammanfattning : The cell cycle progression is tightly regulated to ensure error-free cell replication. The complexity of the transcriptional machinery aids to function in a spatiotemporal pattern across different phases and genomic loci. LÄS MER