Sökning: "Phase II"

Visar resultat 1 - 5 av 1308 avhandlingar innehållade orden Phase II.

  1. 1. Synthesis of Aldehyde-Functionalized Building Blocks and Their Use for the Cyclization of Peptides : Applications to Angiotensin II

    Författare :Petra Johannesson; Rob M. J. Liskamp; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Synthesis; Aldehyde; Cyclization; Peptide; Angiotensin II; Ang II; Bioactive Conformation; Solid Phase Peptide Synthesis; Dimethyl Acetal; Farmaceutisk kemi; Syntes; Aldehyd; Cyklisering; Peptid; Bioaktiv konformation; Fast-fas peptidsyntes; Dimetylacetal; Pharmaceutical chemistry; Farmaceutisk kemi; Organic Pharmaceutical Chemistry; organisk farmaceutisk kemi;

    Sammanfattning : This study addresses the issue of how to convert peptides into drug-like non- peptides with retained biological activities at peptide receptors. Angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe, Ang II) was used as a model peptide. LÄS MER

  3. 2. Benefits of Non-Linear Mixed Effect Modeling and Optimal Design : Pre-Clinical and Clinical Study Applications

    Författare :Charles Ernest II; Andrew Hooker; Mats Karlsson; Bart Ploeger; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; optimal design; nonlinear mixed effects models; population models; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : Despite the growing promise of pharmaceutical research, inferior experimentation or interpretation of data can inhibit breakthrough molecules from finding their way out of research institutions and reaching patients. This thesis provides evidence that better characterization of pre-clinical and clinical data can be accomplished using non-linear mixed effect modeling (NLMEM) and more effective experiments can be conducted using optimal design (OD). LÄS MER

  4. 3. Phase transformation and surface chemistry of secondary iron minerals formed from acid mine drainage

    Författare :Jörgen Jönsson; Lars Lövgren; Per Persson; Staffan Sjöberg; Douglas B Kent; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Inorganic chemistry; schwertmannite; goethite; lepidocrocite; acid mine drainage; sulphate; natural organic matter; mineral surface; infrared spectroscopy; EXAFS; XRD; ternary surface complex; copper II ; cadmium II ; lead II ; zinc II ; Oorganisk kemi; Inorganic chemistry; Oorganisk kemi; Inorganic Chemistry; oorganisk kemi;

    Sammanfattning : The mining of sulphidic ore to extract metals such as zinc and copper produces huge quantities of waste material. The weathering and oxidation of the waste produces what is commonly known as Acid Mine Drainage (AMD), a dilute sulphuric acid rich in Fe(II) and heavy metals. LÄS MER

  5. 4. Fundamental in-situ and ex-situ studies of energy storage related materials including different applications of voltammetry

    Författare :Ulrik Palmqvist; Patrice Millet; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ni-Cd pocket plate batteries; b-Ni OH 2; b-NiOOH; failures; goethite; surface complexation; Pb II ; Zn II ; Cu II ; Cd II ; in-situ; carbon; nanostructured; voltammetry; X-ray diffraction; electrical test; potentiometry; TEM; chlorination; oorganisk kemi; Inorganic Chemistry;

    Sammanfattning : This thesis is a summary and discussion of eight papers dealing with failures and structural aspects of Ni-Cd industrial pocket plate batteries, applications of voltammetry in adsorption studies on goethite (a-FeOOH) surfaces and synthesis and characterisation of nanostructured carbons. The work consists of different areas of chemistry; electrochemistry, structural chemistry and solution chemistry. LÄS MER

  7. 5. Phase Noise in Communication Systems--Modeling, Compensation, and Performance Analysis

    Författare :M Reza Khanzadi; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; multiple antennas; distributed oscillators.; colored phase noise; free-running oscillator; Bayesian Cramér-Rao bound; Oscillator phase noise; phase noise model; channel capacity; mean square error; capacity achieving distribution; Wiener process; extended Kalman filter smoother; maximum a posteriori estimator; phase-locked loop;

    Sammanfattning : The continuous increase in demand for higher data rates due to applications with massive number of users motivates the design of faster and more spectrum efficient communication systems. In theory, the current communication systems must be able to operate close to Shannon capacity bounds. LÄS MER