Sökning: "dose response"

Visar resultat 1 - 5 av 776 avhandlingar innehållade orden dose response.

  1. 1. DNA Damage Response of Normal Epidermis in the Clinical Setting of Fractionated Radiotherapy Evidence of a preserved low-dose hypersensitivity response

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Fredrik Qvarnström; Uppsala universitet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA damage response; low-dose hypersensitivity; dose response; normal tissue; epidermis; keratinocyte; fractionated radiotherapy; DNA double strand break; DSB; foci; γH2AX; 53BP1; checkpoint; p21; apoptosis; mitosis; MEDICINE Surgery Oncology; MEDICIN Kirurgi Onkologi; Oncology; onkologi;

    Sammanfattning : Investigations of DNA damage response (DDR) mechanisms in normal tissues have implications for both cancer prevention and treatments. The accumulating knowledge about protein function and molecular markers makes it possible to directly trace and interpret cellular DDR in a tissue context. LÄS MER

  2. 2. Quantification of Radiation Induced DNA Damage Response in Normal Skin Exposed in Clinical Settings

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Martin Simonsson; Uppsala universitet.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA damage response; low-dose hypersensitivity; dose response; normal tissue; epidermis; dermis; keratinocyte; fractionated radiotherapy; DNA double strand break; DSB; foci; gamma-H2AX; 53BP1; p21; checkpoint; apoptosis; mitosis; micro-RNA; miR-34a; MEDICINE Surgery Oncology; MEDICIN Kirurgi Onkologi; Oncology; Onkologi;

    Sammanfattning : The structure, function and accessibility of epidermal skin provide aunique opportunity to study the DNA damage response (DDR) of a normaltissue. The in vivo response can be examined in detail, at a molecularlevel, and further associated to the structural changes, observed at atissue level. LÄS MER

  3. 3. Improved dose response modeling for normal tissue damage and therapy optimization

    Detta är en avhandling från Stockholm : Medicinsk strålningsfysik (tills m KI)

    Författare :Magdalena Adamus-Górka; Stockholms universitet.; [2008]
    Nyckelord :Normal tissue complications; radiobiological models; dose-response; volume effect; spinal cord; effective FSU size; medicinsk strålningsfysik; Medical Radiation Physics;

    Sammanfattning : The present thesis is focused on the development and application of dose response models for radiation therapy. Radiobiological models of tissue response to radiation are an integral part of the radiotherapeutic process and a powerful tool to optimize tumor control and minimize damage to healthy tissues for use in clinical trials. LÄS MER

  4. 4. In vivo dose, dose-response and cancer risk assessment

    Detta är en avhandling från Stockholm : Stockholms universitet

    Författare :Fredrik Granath; Stockholms universitet.; [1998]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MATHEMATICS Applied mathematics Mathematical statistics; MATEMATIK Tillämpad matematik Matematisk statistik; matematisk statistik; Mathematical Statistics;

    Sammanfattning : .... LÄS MER

  5. 5. Optimal (Adaptive) Design and Estimation Performance in Pharmacometric Modelling

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Alan Maloney; Uppsala universitet.; [2012]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Phase II; dose response; optimal design; adaptive design; exposure response; count data;

    Sammanfattning : The pharmaceutical industry now recognises the importance of the newly defined discipline of pharmacometrics. Pharmacometrics uses mathematical models to describe and then predict the performance of new drugs in clinical development. LÄS MER