Sökning: "nitric-oxide synthase"

Visar resultat 31 - 35 av 189 avhandlingar innehållade orden nitric-oxide synthase.

1. 31. Inducible nitric oxide synthase : in vascular smooth muscle cells

   Författare :Zhong-qun Yan; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :nitric oxide; nitric oxide synthase; vascular smooth muscle cells; transcriptional regulation; NF-[kappa]B; I[kappa]B; pathophysiological role;

   Sammanfattning : Besides the constitutively expressed nitric oxide synthase (NOS) in endothelial cells, vascular smooth muscle cells (SMC) have the potential to express the inducible isoform of NOS (iNOS). Given the important effects of nitric oxide and the high output of this enzyme, expression of iNOS in SMC and its pathophysiological significance were investigated in the present study. LÄS MER

3. 32. The prefrontal cortex and information processing : nitric oxide signaling studied in an animal model of schizophrenia

   Författare :Kim Fejgin; Göteborgs universitet; []
   Nyckelord :schizophrenia; nitric oxide; prepulse inhibition; phencyclidine; prefrontal cortex; cGMP; baclofen; cognition;

   Sammanfattning : The prefrontal cortex has been extensively linked to several cognitive domains that are severely compromised in schizophrenia. It has therefore become a key region for studies on the disabling cognitive dysfunction commonly observed in patients with schizophrenia. LÄS MER

4. 33. Cognition and social behaviour in schizophrenia: An animal model investigating the potential role of nitric oxide

   Författare :Caroline Wass; Göteborgs universitet; []
   Nyckelord :schizophrenia; cognition; memory; Morris water maze; social function; social interaction; phencyclidine; nitric oxide; L-NAME; rat;

   Sammanfattning : Cognitive deficits are the single strongest predictor of functional outcome in patients with schizophrenia. Furthermore, these deficits are not satisfactorily alleviated by available antipsychotic treatment. LÄS MER

5. 34. Prevention of type 1 diabetes mellitus in experimental studies

   Författare :Maria Holstad; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Cytokines; inducible nitric oxide synthase; nitric oxide; NOD mice; pancreatic islets; prolactin; syngeneic islet transplantation; tumour necrosis factor alpha; type 1 diabetes mellitus; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

   Sammanfattning : The aim of the study was to examine the immune response and different immunoprotective strategies in experimental type 1 diabetes mellitus. The autoimmune destruction of the insulin-producing pancreatic β-cells that leads to type 1 diabetes is complex and incompletely understood. LÄS MER

7. 35. Macrophages, Nitric oxide synthases and Heme oxygenases: possible roles during peripheral nerve regeneration

   Författare :Sofia Magnusson; Biologiska institutionen; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; satellite cells; peripheral ganglia; cell signalling; nerve regeneration; heme oxygenase; Macrophages; nitric oxide synthase; Animal physiology; Djurfysiologi;

   Sammanfattning : The purpose of this study was to investigate the suggestions that macrophages, and the systems generating nitric oxide (NO) and carbon monoxide (CO), i.e. nitric oxide synthases (NOS) and heme oxygenases (HO), could be important for peripheral nerve regeneration. LÄS MER