Sökning: "NOD mice"

Visar resultat 1 - 5 av 57 avhandlingar innehållade orden NOD mice.

  1. 1. The genetic basis of T and B cell contribution to autoimmune diabetes in NOD mice

    Detta är en avhandling från Umeå : Medicinsk biovetenskap

    Författare :Vinícius Motta; Umeå universitet.; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 Diabetes; NOD mouse; CTLA-4; superantigen; T cells; Idd; marginal zone B cells; embryo aggregation chimera; negative selection; MEDICINE Microbiology; immunology; infectious diseases Immunology Immunogenetics; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Immunologi Immungenetik;

    Sammanfattning : The nonobese diabetic mouse (NOD) is an excellent animal model to study type 1 diabetes. As with some humans, disease in the NOD mouse is effected by a combination of genetic and environmental factors. At least 20 insulin dependent diabetes (Idd) susceptibility loci have been identified so far, both in humans and in the NOD mouse. LÄS MER

  2. 2. Anomalies in humoral immunity in the NOD mouse contribution to the progression of type 1 diabetes

    Detta är en avhandling från Umeå : Umeå University

    Författare :Radha Thyagarajan; Umeå universitet.; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 Diabetes; NOD mouse; B cells; IgE; TACI; BAFF; immunologi; Immunology;

    Sammanfattning : The non-obese diabetic (NOD) mouse is widely used model Type 1 diabetes (T1D), a chronic inflammatory disease characterized by destruction of the insulin producing β cells in the islets of Langerhans by immune cells. The classical symptoms include increased glucose levels in urine and blood, frequent urination and enhanced thirst. LÄS MER

  3. 3. MHCI-E mediated protection from IDDM on NOD mice : The role of regulatory T cells

    Detta är en avhandling från Stockholm : Stockholm University

    Författare :Nina Brenden; Stockholms universitet.; [1998]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Immunology; immunologi;

    Sammanfattning : .... LÄS MER

  4. 4. Islet insulin secretory patterns in diabetes and the role of UCP2

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Jian-Man Lin; Uppsala universitet.; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; type 1 diabetes; type 2 diabetes; NOD; GK; congenes; KKAy; human; islet; glucose; insulin release; oscillation; frequency; amplitude; oxidation; respiration; UCP2; western blot; Cellbiologi; MEDICINE Morphology; cell biology; pathology Cell biology; MEDICIN Morfologi; cellbiologi; patologi Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : During development of type 1 and type 2 diabetes plasma insulin patterns are altered. Since the islet insulin release pattern has been implicated in this development, insulin secretion from single islets was studied and linked to the islet protein levels of uncoupling protein-2 (UCP2). LÄS MER

  5. 5. Cytokine regulation of pancreatic -cell function with special reference to the pathogenesis of type 1 diabetes

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Johnny Sternesjö; Uppsala universitet.; [1999]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Diabetes; pancreatic islets; insulin secretion; cytokines; nitric oxide; streptozotocin; NOD mice; proteasome; nuclear factor-kappaB; Cellbiologi; MEDICINE Morphology; cell biology; pathology Cell biology; MEDICIN Morfologi; cellbiologi; patologi Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : Cytokines produced by inflammatory cells have been implicated in the pathogenesis of type 1 diabetes. The overall aim of the present work was to test how different cytokines, supposed to be present in the insulitic lesion, could influence the function of islets of Langerhans. LÄS MER