Sökning: "prepulse inhibition"
Visar resultat 1 - 5 av 16 avhandlingar innehållade orden prepulse inhibition.
1. Cognitive function studied in animal models of schizophrenia
Sammanfattning : Cognitive dysfunction is considered a core deficit of schizophrenia, which currently lacks effective pharmacological treatment. In order to identify novel and more effective drug treatments, translational experimental animal models of cognitive dysfunction are required. Schizophrenia-like symptoms can be induced in humans by phencyclidine (PCP). LÄS MER
2. The Effect of Steroid Hormones in the Female Brain During Different Reproductive States
Sammanfattning : Women are twice as likely as men to suffer from depression and anxiety disorders and have an increased risk of onset during periods associated with hormonal changes, such as the postpartum period and the menopausal transition. Furthermore, some women seem more sensitive to normal hormone fluctuations across the menstrual cycle, since approximately 3-5% suffers from premenstrual dysphoric disorder (PMDD). LÄS MER
3. The prefrontal cortex and information processing : nitric oxide signaling studied in an animal model of schizophrenia
Sammanfattning : The prefrontal cortex has been extensively linked to several cognitive domains that are severely compromised in schizophrenia. It has therefore become a key region for studies on the disabling cognitive dysfunction commonly observed in patients with schizophrenia. LÄS MER
4. Schizophrenia and Nitric Oxide: Deficits in Information Processing Invetigated in Animal Models
Sammanfattning : Rationale: Schizophrenia-like symptoms can be induced in humans by phencyclidine (PCP), a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor. Schizophrenic patients and PCP-treated animals display deficits in pre-attentive information processing, as assessed by e.g. prepulse inhibition of the acoustic startle response. LÄS MER
5. Hormones, Mood and Cognition
Sammanfattning : Ovarian steroid hormones are neuroactive steroids with widespread actions in the brain, and are thus able to influence mood, behavior and cognition. In this thesis the effects of progesterone withdrawal and the direct effects of the progesterone metabolite allopregnanolone are evaluated. LÄS MER