Sökning: "phencyclidine"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet phencyclidine.

  1. 1. Cognitive function studied in animal models of schizophrenia

    Författare :Erik Pålsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; phencyclidine; nitric oxide; prepulse inhibition; latent; nitric oxide; prepulse inhibition; latent inhibition; habituation; NMDA receptor; rat; mouse; cognition; schizophrenia;

    Sammanfattning : Cognitive dysfunction is considered a core deficit of schizophrenia, which currently lacks effective pharmacological treatment. In order to identify novel and more effective drug treatments, translational experimental animal models of cognitive dysfunction are required. Schizophrenia-like symptoms can be induced in humans by phencyclidine (PCP). LÄS MER

  3. 2. Cognition and social behaviour in schizophrenia: An animal model investigating the potential role of nitric oxide

    Författare :Caroline Wass; Göteborgs universitet; []
    Nyckelord :schizophrenia; cognition; memory; Morris water maze; social function; social interaction; phencyclidine; nitric oxide; L-NAME; rat;

    Sammanfattning : Cognitive deficits are the single strongest predictor of functional outcome in patients with schizophrenia. Furthermore, these deficits are not satisfactorily alleviated by available antipsychotic treatment. LÄS MER

  4. 3. The prefrontal cortex and information processing : nitric oxide signaling studied in an animal model of schizophrenia

    Författare :Kim Fejgin; Göteborgs universitet; []
    Nyckelord :schizophrenia; nitric oxide; prepulse inhibition; phencyclidine; prefrontal cortex; cGMP; baclofen; cognition;

    Sammanfattning : The prefrontal cortex has been extensively linked to several cognitive domains that are severely compromised in schizophrenia. It has therefore become a key region for studies on the disabling cognitive dysfunction commonly observed in patients with schizophrenia. LÄS MER

  5. 4. The phencyclidine model of schizophrenia : dysregulation of brain dopamine systems induced by NMDA receptor antagonists

    Författare :Jan M Mathé; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :phencyclidine; MK-801; CNQX; prazosin; tetrodotoxin; dopamine; neurotensin; ventral tegmental area; nucleus accumbens; medial prefrontal cortex;

    Sammanfattning : Non-competitive NMDA receptor antagonists, such as phencyclidine (PCP) and dizocilpine (MK-801) can even acutely induce a drug induced psychotic state which closely resembles schizophrenia. The midbrain dopamine (DA) neurons, which originate in the ventral tegmental area (VTA), are involved in motivational, attentional and cognitive processes, and have also been profoundly implicated in schizophrenia. LÄS MER

  7. 5. On the role of forebrain cholinergic innervation for phencyclidine-induced behaviors and gene expression patterns

    Författare :Sophia Savage; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The basalo-cortical cholinergic innervation reaches neural targets in cortex cerebri where it modulates the incoming sensory information, regulating arousal, attention, vigilance, memory and cognition. Progressive de generation of the cholinergic neurons in the basal forebrain is considered a hallmark of Alzheimer ’s disease related to cognitive impairment in this condition. LÄS MER