Sökning: "metalloproteases"

Visar resultat 1 - 5 av 18 avhandlingar innehållade ordet metalloproteases.

1. 1. rd1 Photoreceptor Degeneration: Photoreceptor Rescue and Role of Metalloproteases in Retinal Degeneration

   Författare :Poonam Ahuja Jensen; Allmänmedicin och samhällsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oftalmologi; Ophtalmology; retinal degeneration; Survival factors; metalloproteases;

   Sammanfattning : The thesis is focused on an attempt to delay photoreceptor cell death in the rd1 mouse using Lens Epithelium Derived Growth Factor (LEDGF), Glutathione S-Transferase mu (GST-?? and Glutathione S-Transferase alpha (GST-?? in an organ culture paradigm as well as the role of metalloproteases (MMPs) and their tissue inhibitors in photoreceptor degeneration (TIMPs). The rd1 mouse model displays a retina degeneration which starts around day 10 with rod photoreceptor cell death. LÄS MER

3. 2. Matrix metalloproteases and cell motility in malignant mesothelioma

   Författare :Zhiwen Liu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Matrix; metalloproteases MMPs ; cell motility; growth factors; malignant mesothelioma; invasion;

   Sammanfattning : Invasion and metastasis of malignant tumor cells requires destruction of and migration through extracellular matrix (ECM) such as basement membrane and interstitial stroma. The ECM-degrading proteases produced by tumor cells and stromal cells and cell motility play a crucial role in this process. LÄS MER

4. 3. The effects of flaxseed and tamoxifen on the inflammatory microenvironment in normal breast tissue and in breast cancer

   Författare :Gabriel Lindahl; Charlotta Dabrosin; Signe Borquist; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer; inflammation; chemoprevention; tamoxifen; phytoestrogens; flaxseed; enterolactone; interleukins; osteopontin; chemokines; matrix metalloproteases; microdialysis;

   Sammanfattning : Breast cancer is the most common cancer among women worldwide today. Nearly 9000 women are diagnosed with breast cancer in Sweden yearly and despite advantages in diagnostics and treatments approximately 1400 women still die from their disease every year. LÄS MER

5. 4. FtsH metalloproteases and their pseudo-proteases in the chloroplast envelope of Arabidopsis thaliana

   Författare :Laxmi S. Mishra; Christiane Funk; Magnus Wolf-Watz; Catherine de Vitry; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Arabidopsis thaliana; AAA-ATPases; abscisic acid; chloroplast; drought; embryo-lethal; FtsH metalloprotease; intrinsic water-use efficiency WUEi ; leaf variegation; outdoor conditions; oxidative stress; plastid biogenesis; proteomics; protein import; root-associated bacterial communities seedlings; Biochemistry; biokemi; molekylärbiologi; Molecular Biology; biology; biologi;

   Sammanfattning : By cleaving peptide bonds, proteases either activate or degrade proteins and maintain protein quality control in response to various developmental stimuli and environmental factors. My work has focused on elucidating the role of the filamentation temperature sensitive protein H (FtsH) proteases. LÄS MER

7. 5. Studies of cell migration and matrix protease production in human lung cancer cell lines

   Författare :Cecilia G Bredin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Lung cancer; extracellular matrix; growth factors; matrix metalloproteases; integrins; migration; invasion;

   Sammanfattning : Metastatic spread in cancer is a complex multistep process involving continuous, sequential interactions between tumour cells and their respective microenvironment. Invasiveness per se has not been studied in this thesis, only some of its major components, such as cell migration and matrix protease production. LÄS MER