Sökning: "retinal degeneration"

Visar resultat 1 - 5 av 51 avhandlingar innehållade orden retinal degeneration.

  1. 1. Retinal Transplants: Growth Differentiation Integration Organization and Survival

    Författare :Rajesh Kumar Sharma; Lund Oftalmologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; retinal degeneration; Retinal transplants; retinal development; treatment; connections; proliferation; survival; Ophtalmology; Oftalmologi;

    Sammanfattning : The goal of the study was to get a better understanding of factors controlling the growth, differen-tia-tion, integration, organization and survival of retinal transplants, with the long-term view of eventually developing retinal transplantation into a clinically useful procedure for treating degenerative retinal disorders such as retinitis pigmentosa. Embryonic day 15 rabbit retinas were transplanted into adult rabbit eyes and were allowed to survive for various times. LÄS MER

  3. 2. rd1 Photoreceptor Degeneration: Photoreceptor Rescue and Role of Metalloproteases in Retinal Degeneration

    Författare :Poonam Ahuja Jensen; Allmänmedicin och samhällsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oftalmologi; Ophtalmology; retinal degeneration; Survival factors; metalloproteases;

    Sammanfattning : The thesis is focused on an attempt to delay photoreceptor cell death in the rd1 mouse using Lens Epithelium Derived Growth Factor (LEDGF), Glutathione S-Transferase mu (GST-?? and Glutathione S-Transferase alpha (GST-?? in an organ culture paradigm as well as the role of metalloproteases (MMPs) and their tissue inhibitors in photoreceptor degeneration (TIMPs). The rd1 mouse model displays a retina degeneration which starts around day 10 with rod photoreceptor cell death. LÄS MER

  4. 3. Genes and proteins controlled by cGMP-PKG during retinal degeneration

    Författare :Jiaming Zhou; Lund Oftalmologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; retinal degeneration; cell death; cGMP-PKG; organotypic explant culture; RNA sequencing; mass spectrometry;

    Sammanfattning : prevalence was reported as 1:3000-4000 worldwide, making it the main reason for blindness in the working population in industrial countries. The mutations of over 70 genes have been related to this genetic disorder, and there is generally no effective treatment, except for gene therapy for the RPE65 mutations. LÄS MER

  5. 4. Retinal function in deaf-blind syndromes

    Författare :Eva Malm; Lund Oftalmologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; general anesthesia.; molecular genetics; hearing impairment; full-field electroretinography; Retinal degeneration;

    Sammanfattning : A variety of disorders can cause retinal degeneration and hearing impairment, and it is of great value to have an early diagnosis since there is a large variation in phenotype and prognosis both within and between the different disorders. The general aim of this thesis was to characterize the retinal function, to describe the phenotype, and – where appropriate – to relate the phenotype to genotype in patients with combined visual and hearing impairment. LÄS MER

  7. 5. The potential role of retinal cGMP-interaction partners within the degeneration mechanism causing Retinitis Pigmentosa

    Författare :Michel Rasmussen; Lund Oftalmologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Retinitis Pigmentosa; Photoreceptors; cGMP; cGMP-interactors; retinal degeneration; neuroprotection;

    Sammanfattning : The eye disease Retinitis Pigmentosa (RP) represents a heterogeneous group of inherited retinal dystrophies, and it has been estimated that 1 in 3000 to 7000 people worldwide has the disease. The symptoms of RP are photoreceptor degeneration that leads to night blindness, followed by a decline in peripheral and central vision, and potential blindness. LÄS MER