Sökning: "retinal degeneration"

Visar resultat 1 - 5 av 46 avhandlingar innehållade orden retinal degeneration.

  1. 1. Retinal Transplants: Growth Differentiation Integration Organization and Survival

    Detta är en avhandling från Department of Ophthalmology, Lund University

    Författare :Rajesh Kumar Sharma; [1999]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; retinal degeneration; Retinal transplants; retinal development; treatment; connections; proliferation; survival; Ophtalmology; Oftalmologi;

    Sammanfattning : The goal of the study was to get a better understanding of factors controlling the growth, differen-tia-tion, integration, organization and survival of retinal transplants, with the long-term view of eventually developing retinal transplantation into a clinically useful procedure for treating degenerative retinal disorders such as retinitis pigmentosa. Embryonic day 15 rabbit retinas were transplanted into adult rabbit eyes and were allowed to survive for various times. LÄS MER

  2. 2. rd1 Photoreceptor Degeneration: Photoreceptor Rescue and Role of Metalloproteases in Retinal Degeneration

    Detta är en avhandling från Ophthalmology (Lund), Lund University

    Författare :Poonam Ahuja Jensen; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oftalmologi; Ophtalmology; retinal degeneration; Survival factors; metalloproteases;

    Sammanfattning : The thesis is focused on an attempt to delay photoreceptor cell death in the rd1 mouse using Lens Epithelium Derived Growth Factor (LEDGF), Glutathione S-Transferase mu (GST-?? and Glutathione S-Transferase alpha (GST-?? in an organ culture paradigm as well as the role of metalloproteases (MMPs) and their tissue inhibitors in photoreceptor degeneration (TIMPs). The rd1 mouse model displays a retina degeneration which starts around day 10 with rod photoreceptor cell death. LÄS MER

  3. 3. Retinal function in deaf-blind syndromes

    Detta är en avhandling från Department of Clinical Sciences, Lund University

    Författare :Eva Malm; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; general anesthesia.; molecular genetics; hearing impairment; full-field electroretinography; Retinal degeneration;

    Sammanfattning : A variety of disorders can cause retinal degeneration and hearing impairment, and it is of great value to have an early diagnosis since there is a large variation in phenotype and prognosis both within and between the different disorders. The general aim of this thesis was to characterize the retinal function, to describe the phenotype, and – where appropriate – to relate the phenotype to genotype in patients with combined visual and hearing impairment. LÄS MER

  4. 4. Electrophysiology and optical coherence tomography in acquired and hereditary retinal disorders

    Detta är en avhandling från Department of Ophthalmology, Lund University

    Författare :Patrik Schatz; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Retinal degeneration; multifocal ERG; Oftalmologi; Ophtalmology; OCT;

    Sammanfattning : In this thesis, retinal function in general, as well as central retinal function and structure are described in selected forms of acquired and hereditary retinal disorders, in order to improve our understanding of underlying pathogenic mechanisms. This comparison has been made possible during the last years, through the relatively recent development of multifocal ERG (mfERG) and optical coherence tomography (OCT) for the analysis of central retinal function and structure, respectively. LÄS MER

  5. 5. Retinal pigment epithelial cells, oxidative stress and lipofuscin : relation to age-related macular degeneration

    Detta är en avhandling från Linköping : Linköpings universitet

    Författare :Staffan Sundelin; Stefan Seregard; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE; MEDICIN;

    Sammanfattning : In developed countries, age-related macular degeneration (AMD) is the most common cause of loss of central vision in people over the age of 65. The retinal pigment epithelium (RPE) appears to be the site of early pathological changes in AMD. LÄS MER