Sökning: "malignant mesothelioma"

Visar resultat 1 - 5 av 19 avhandlingar innehållade orden malignant mesothelioma.

  1. 1. Matrix metalloproteases and cell motility in malignant mesothelioma

    Författare :Zhiwen Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Matrix; metalloproteases MMPs ; cell motility; growth factors; malignant mesothelioma; invasion;

    Sammanfattning : Invasion and metastasis of malignant tumor cells requires destruction of and migration through extracellular matrix (ECM) such as basement membrane and interstitial stroma. The ECM-degrading proteases produced by tumor cells and stromal cells and cell motility play a crucial role in this process. LÄS MER

  3. 2. Hyaluronan in malignant pleural mesothelioma with special reference to diagnosis, tumourbiology and prognosis

    Författare :Anders Thylén; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Malignant pleural mesothelioma; hyaluronan; prognosis; methods; immunohistochemistry; tumourvolume; chemotherapy; tirapazamine; cisplatin;

    Sammanfattning : Malignant pleural mesothelioma (MPM), the primary malignant tumour of the pleural cavity, is an uncommon and treatment resistant tumour. The prognosis is poor. In many, but not all cases the concentration of hyaluronan (Hya) is increased in pleural effusion. The clinical relevance of Hya in MPM is not clear. LÄS MER

  4. 3. Malignant pleural mesothelioma : novel biomarkers and related pathways

    Författare :Filip Mundt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Malignant mesothelioma is an asbestos induced cancer that is difficult to diagnose. Several studies have combined biomarkers to improve mesothelioma diagnosis, but with moderate success, and there is a need for new mesothelioma biomarkers. The tumour is often resistant to treatment and most patients will survive less than a year. LÄS MER

  5. 4. Experimental therapeutics against malignant mesothelioma : investigations in vitro

    Författare :Gustav Nilsonne; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Malignant mesothelioma is a tumour of the mesothelium, a specialized tissue found in the pleura, pericardium, peritoneum, and tunica vaginalis testis. The tumour has strong etiological links to asbestos, with a latency period ranging up to several decades between asbestos exposure and tumour diagnosis. LÄS MER

  7. 5. Studies on mesothelial differentiation : prognostic and therapeutic approaches to malignant mesothelioma

    Författare :Xiaojuan Sun; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Mesothelium; Differentiation; Malignant Mesothelioma; Proteasome; Selenium; Thioredoxin;

    Sammanfattning : Malignant mesothelioma (MM), a tumor with a poor prognosis, causes the death of most patients within a year of diagnosis since various treatments seem to have little effect on its outcome. The biological behavior of MM varies greatly, and this heterogeneity is related to its morphology, which may be epithelioid, sarcomatoid (fibroblastoid) or biphasic, the sarcomatoid phenotype being associated with a shorter survival. LÄS MER