Sökning: "metalloproteases MMPs"

Hittade 5 avhandlingar innehållade orden metalloproteases MMPs.

  1. 1. rd1 Photoreceptor Degeneration: Photoreceptor Rescue and Role of Metalloproteases in Retinal Degeneration

    Författare :Poonam Ahuja Jensen; Allmänmedicin och samhällsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oftalmologi; Ophtalmology; retinal degeneration; Survival factors; metalloproteases;

    Sammanfattning : The thesis is focused on an attempt to delay photoreceptor cell death in the rd1 mouse using Lens Epithelium Derived Growth Factor (LEDGF), Glutathione S-Transferase mu (GST-?? and Glutathione S-Transferase alpha (GST-?? in an organ culture paradigm as well as the role of metalloproteases (MMPs) and their tissue inhibitors in photoreceptor degeneration (TIMPs). The rd1 mouse model displays a retina degeneration which starts around day 10 with rod photoreceptor cell death. LÄS MER

  3. 2. Matrix metalloproteases and cell motility in malignant mesothelioma

    Författare :Zhiwen Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Matrix; metalloproteases MMPs ; cell motility; growth factors; malignant mesothelioma; invasion;

    Sammanfattning : Invasion and metastasis of malignant tumor cells requires destruction of and migration through extracellular matrix (ECM) such as basement membrane and interstitial stroma. The ECM-degrading proteases produced by tumor cells and stromal cells and cell motility play a crucial role in this process. LÄS MER

  4. 3. Studies of cell migration and matrix protease production in human lung cancer cell lines

    Författare :Cecilia G Bredin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Lung cancer; extracellular matrix; growth factors; matrix metalloproteases; integrins; migration; invasion;

    Sammanfattning : Metastatic spread in cancer is a complex multistep process involving continuous, sequential interactions between tumour cells and their respective microenvironment. Invasiveness per se has not been studied in this thesis, only some of its major components, such as cell migration and matrix protease production. LÄS MER

  5. 4. Matrix degrading proteases in the ovary : expression and function

    Författare :Patrik Wahlberg; Tor Ny; Ilpo Huhtaniemi; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; ovary; ovulation; corpus luteum; plasminogen; PA; MMP; rat; mouse; Biokemi; Biochemistry; Biokemi; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : Extracellular matrix degrading proteases from the plasminogen (plg) activator (PA) and the matrix metalloproteinase (MMP) systems have been implicated as important mediators of ovulation and corpus luteum (CL) formation and regression. The aim of this thesis was to investigate the expression and regulation of PAs and MMPs in the ovary and to examine their functional roles for CL formation and function. LÄS MER

  7. 5. TGFβ Signal Transduction in Endothelial Cells

    Författare :Gudrun Valdimarsdóttir; Peter ten Dijke; Carl-Henrik Heldin; Christer Betsholtz; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Cellbiologi; Cell biology; Cellbiologi;

    Sammanfattning : Transforming growth factor β (TGFβ) is a multifunctional cytokine that is involved in many biological effects, such as proliferation, migration, differentiation and cell survival. TGFβ regulates cellular responses by binding to a heteromeric complex of type I and type II serine/threonine kinase receptors. LÄS MER