Sökning: "intestinal tumor"

Visar resultat 21 - 25 av 66 avhandlingar innehållade orden intestinal tumor.

  1. 21. Regulation of the cytoskeleton and the adhesiveness of intestinal epithelial cells by leukotriene D4

    Författare :Ramin Massoumi; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; patologisk anatomi; Patologi allmän ; pathological anatomy; General pathology; PKC; vinculin; actin filament; focal adhesion; LTD4; integrin; cancerology; Cytologi; onkologi; cancer; Biochemistry; Metabolism; Biokemi; metabolism;

    Sammanfattning : Leukotrienes belong to a family of biologically active conjugated trienes that are formed from arachidonic acid via the 5-lipoxygenase pathway and are important mediators of inflammatory reactions. The CysLT1 receptor that specifically serves as receptor for leukotriene D4 (LTD4) has been identified as a G-protein coupled receptor. LÄS MER

  3. 22. Isoform-specific regulation of Drosophila gut immunity and regeneration by the POU/Oct transcription factor Nub/Pdm1

    Författare :Xiongzhuo Tang; Ylva Engström; Tony Ip; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; POU; Nubbin; Drosophila; intestinal stem cell; epithelium regeneration; midgut; mitosis; Antimicrobial peptides; innate immunity; NF-κB; bacterial infection; transcriptional regulation; homeostasis; Molecular Biology; molekylärbiologi;

    Sammanfattning : Innate immune reactions protect organisms against a variety of infections.  In metazoans, these reactions involve both cellular and humoral responses. The immune responses have to be well-tuned, as excessive immune activation is associated with tissue-specific pathologies. LÄS MER

  4. 23. In vitro studies on intestinal epithelial cell proliferation : effects of cytokines, Helicobacter pylori, serotonin and neuroendocrine peptides

    Författare :Kristina Zachrisson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Ammonia; Apoptosis; cell culture; cytokines; DNA synthesis; FHs-74 cells; Helicobacter pylori; IEC-6 cells; mitosis; neuroendocrine peptides; organ culture; serotonin;

    Sammanfattning : Previous studies suggest that bacteria and bacterial metabolites, proinflammatory cytokines, neuroendocrine peptides and amines may participate in the regulation of the gastrointestinal-epithelial cell kinetics. The complexity of interactions that take place in vivo makes it difficult to define the primary actions of these and other agents on gastrointestinal cell proliferation. LÄS MER

  5. 24. Pancreatic cancer : investigation of the prognostic significance of tumor immunophenotype and establishment of a novel ex-vivo tissue slice culture system for drug sensitivity testing

    Författare :Carlos Fernández Moro; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Pancreatic ductal adenocarcinoma (PDAC), commonly referred to as pancreatic cancer, is associated with a dismal 5-year overall survival of 9 to 6 %. A major reason for the high mortality is the pronounced resistance to treatment. LÄS MER

  7. 25. Functional role of a constitutively active dioxin/Ah receptor in a transgenic mouse model

    Författare :Patrik Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Dioxin Ah receptor; TCDD; dioxin; stomach tumor; osteopontin; peritoneal B1 B cells; transcription factor; gene expression;

    Sammanfattning : The dioxin/ Aryl hydrocarbon receptor is a ligand-activated transcription factor that mediates most (if not all) of the toxic effects of the group of highly potent environmental pollutants collectively called dioxins and PCBs, including the highly toxic compound 2,3,7,8tetrachlorodibenzo-p-dioxin (TCDD). The toxic effects include immune suppression, endocrine disruption, impaired reproduction and carcinogenesis. LÄS MER