Sökning: "Ramin Massoumi"

Hittade 2 avhandlingar innehållade orden Ramin Massoumi.

  1. 1. Regulation of the cytoskeleton and the adhesiveness of intestinal epithelial cells by leukotriene D4

    Författare :Ramin Massoumi; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; patologisk anatomi; Patologi allmän ; pathological anatomy; General pathology; PKC; vinculin; actin filament; focal adhesion; LTD4; integrin; cancerology; Cytologi; onkologi; cancer; Biochemistry; Metabolism; Biokemi; metabolism;

    Sammanfattning : Leukotrienes belong to a family of biologically active conjugated trienes that are formed from arachidonic acid via the 5-lipoxygenase pathway and are important mediators of inflammatory reactions. The CysLT1 receptor that specifically serves as receptor for leukotriene D4 (LTD4) has been identified as a G-protein coupled receptor. LÄS MER

  3. 2. Molecular mechanisms for activation of non-canonical TGFβ pathways and their importance during prostate cancer progression

    Författare :Anahita Hamidi; Marene Landstöm; Carl-Henrik Heldin; Ramin Massoumi; Uppsala universitet; []
    Nyckelord :TGFβ; AKT; PI3K; p85α; TRAF6; TAK1; NF-κB; Src; prostate cancer; PC-3U; cell migration; inflammation; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Sammanfattning : Prostate cancer is the most common invasive cancer diagnosed in men and a major and growing health problem in Western countries. Deregulation of different pathways has been implicated in progression of prostate cancer, namely nuclear factor kappa enhancer binding protein (NF-κB), transforming growth factor β (TGFβ), phosphoinositide 3ʹ-kinase/AKT (PI3K/AKT) and Src kinase pathways. LÄS MER