Sökning: "high throughput screening model"
Visar resultat 21 - 25 av 55 avhandlingar innehållade orden high throughput screening model.
21. Drug Repositioning for Cancer Treatment : Novel Candidate Identification Strategies
Sammanfattning : Regardless of the enormous investments in cancer research and drug development, the proportion of approved drugs in oncology is low compared to other indications, and new avenues are needed. One attractive approach in this regard is drug repositioning where new uses outside the scope of the original medical indications for existing drugs are identified. LÄS MER
22. Toxicological studies of di-n-butyl phthalate (DBP) : Impact on the reproductive system and gut microbiota
Sammanfattning : The potential health impact of exposure to anthropogenic chemicals has raised major concerns worldwide. Phthalates are mainly used in the plastic industry and have been associated with adverse effects in humans. Di-n-butyl phthalate (DBP) is one of the dominant phthalates with a ubiquitous presence in the environment. LÄS MER
23. Ion channels in drug discovery : focus on biological assays
Sammanfattning : Ion channels are well characterised drug targets. However, the techniques used to study ion channel pharmacology have not been particularly applicable to modern drug discovery. LÄS MER
24. Computational models for the prediction of intestinal membrane permeability
Sammanfattning : Lead compounds generated in high-throughput drug discovery programs often have unfavorable biopharmaceutical properties, resulting in a low success rate for such drug candidates in clinical development. Efficient and reliable methods that predict biopharmaceutical properties, such as intestinal permeability and solubility are therefore required in order to reduce the attrition rate during development of these compounds. LÄS MER
25. Bioinformatics tools for discovery and evaluation of biomarkers : Applications in clinical assessment of cancer
Sammanfattning : Cancer is a disease characterized by abnormal proliferation of cells in the body and ranks as the second leading cause of death worldwide. In order to improve cancer patient care, a major focus of cancer research is to discover biomarkers. LÄS MER