Sökning: "Exposome"

Hittade 3 avhandlingar innehållade ordet Exposome.

  1. 1. Toxicoproteomics, from finding molecular targets to evaluating the impact on human health

    Författare :Verónica Lizano Fallas; Susana Cristobal; Maria Jenmalm; Robert Barouki; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Exposome; Chemical risk assessment; Toxicoproteomics; Proteome integral solubility alteration;

    Sammanfattning : The exposome refers to all exposures, including exposures to chemicals, that an individual may encounter over the whole life, from conception to death, that influence the individual’s health. To date, over 200,000 chemicals have been registered under the legislative framework of the European Union. LÄS MER

  3. 2. Toxicological studies of di-n-butyl phthalate (DBP) : Impact on the reproductive system and gut microbiota

    Författare :Radwa Almamoun; Oskar Karlsson; Paula Pierozan; Harri Alenius; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dibutyl phthalate; Antiandrogen; Gut microbiota; Reproductive toxicity; Endocrine disrupting chemicals; Environmental contaminants; Phthalates; Plastics; 3D cell culture model; Exposome; Toxicology; Environmental Sciences; miljövetenskap;

    Sammanfattning : The potential health impact of exposure to anthropogenic chemicals has raised major concerns worldwide. Phthalates are mainly used in the plastic industry and have been associated with adverse effects in humans. Di-n-butyl phthalate (DBP) is one of the dominant phthalates with a ubiquitous presence in the environment. LÄS MER

  4. 3. Optimizing Exposome-wide Assessments in Cardiometabolic Risk

    Författare :Hugo Pomares-Millan; Genetisk och molekylär epidemiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lifestyle; Nutritional epidemiology; Cardiometabolic risk; Prediabetes; cardiovascular disease CVD ; Type 2 diabetes T2D ; Machine learning; causal inference; Mediation analysis; Mendelian randomization;

    Sammanfattning : This thesis is focused on cardiovascular disease (CVD) and type 2 diabetes mellitus (T2D), two concomitant conditions that appear with growing concern. In our work, we aim to improve the identification of individuals at-risk of cardiometabolic disease through the characterization of complex environmental exposures (i.e. LÄS MER