Sökning: "Mårten Fryknäs"
Visar resultat 1 - 5 av 7 avhandlingar innehållade orden Mårten Fryknäs.
1. Molecular Screening for Target Discovery in Cancer
Sammanfattning : Cancer is one of the major causes of death in the western world. Resistance to anti-cancer drugs and diagnostic difficulties are major obstacles to successful treatment. LÄS MER
2. Quiescent cancer cells : Three-dimensional cell models for evaluation of new therapeutics
Sammanfattning : Inadequate metabolic conditions in solid tumors lead to the formation of quiescent cancer cells that are suspended in a transient cell cycle arrest. When conditions change, quiescent cancer cells can re-enter the cell cycle and cause recurrence. LÄS MER
3. Proteomics informed investigation of human hepatocytes and liver tissue
Sammanfattning : A successful drug needs to display beneficial absorption, distribution, metabolism, excretion and toxicity (ADME-Tox) profile. It is therefore important to investigate these properties during the drug discovery process. LÄS MER
4. Drug Repositioning for Cancer Treatment : Novel Candidate Identification Strategies
Sammanfattning : Regardless of the enormous investments in cancer research and drug development, the proportion of approved drugs in oncology is low compared to other indications, and new avenues are needed. One attractive approach in this regard is drug repositioning where new uses outside the scope of the original medical indications for existing drugs are identified. LÄS MER
5. Preclinical tumor-immune modeling : For the identification of immunomodulatory drugs
Sammanfattning : For a long time, the field of cancer research was dominated by a tumor cell-centric view. That, however, changed once it became recognized that medical cancer treatment is largely influenced by the combined effect exerted on both cancer and immune cells. LÄS MER
