Sökning: "functional association"
Visar resultat 21 - 25 av 505 avhandlingar innehållade orden functional association.
21. Functional genetics of the interleukin-4 receptors in allergic asthma
Sammanfattning : Asthma is a complex disorder, with both genetic and environmental factors contributing to disease development. Our aim was to analyse possible associations between genetic variations of immunologically important genes and the susceptibility to and severity of allergic asthma in adults. LÄS MER
22. Human leukocyte antigen in sickness and in health : Ankylosing spondylitis and HLA in Sweden
Sammanfattning : The human leukocyte antigen (HLA) plays a major role in keeping us healthy, but some of the HLA alleles can contribute to disease susceptibility. One example is HLA-B*27, which confers increased susceptibility of ankylosing spondylitis and represents one of the strongest genetic associations found in any common human disease. LÄS MER
23. Heritability of blood pressure: monogenes and polygenes
Sammanfattning : High blood pressure (BP) is associated with cardiovascular morbidity and mortality. Both genetic and environmental factors are implicated in BP homeostatsis and hypertension development. LÄS MER
24. Genetic predisposition for Multiple Myeloma. Identification and functional characterization of risk variants
Sammanfattning : Multiple myeloma (MM) is a blood malignancy originating from plasma cells. First-degree relatives of patients with MM have two- to four-fold higher risk of MM. However, the molecular basis remains largely unknown. This Ph. LÄS MER
25. Functional genomics approaches to dissect causal DNA variations in obesity and type 2 diabetes
Sammanfattning : GWAS studies have identified hundreds of loci that associate with obesity and type 2 diabetes. However, the functional relevance of the genetic variants, and their impact on disease or traits, is largely unknown. LÄS MER