Sökning: "Functional validation"
Visar resultat 1 - 5 av 146 avhandlingar innehållade orden Functional validation.
1. Functional association networks for disease gene prediction
Sammanfattning : Mapping of the human genome has been instrumental in understanding diseasescaused by changes in single genes. However, disease mechanisms involvingmultiple genes have proven to be much more elusive. Their complexityemerges from interactions of intracellular molecules and makes them immuneto the traditional reductionist approach. LÄS MER
2. Long-Term Functional Psychosis : Epidemiology in Two Different Counties in Sweden
Sammanfattning : This thesis is based on two independent studies, the first in Stockholm County (index year 1984; n=302), and the second, a replication and validation study, in Uppsala County (index year 1991; n=455).The general aim was to study all individuals with Long-term Functional Psychosis (LFP) within the two counties of Sweden from an epidemiological perspective and to perform specific studies on a subgroup of individuals with schizophrenia. LÄS MER
3. Protein microarrays for validation of affinity binders
Sammanfattning : Is specificity an important issue regarding affinity reagents? What about the validation of affinity reagents today, is it good enough? This depends on the application and the producer of the reagent. Validation should be the most important marketing argument that can be found. LÄS MER
4. Zebrafish models for large-scale genetic screens in dyslipidemia and atherosclerosis : Validation and application
Sammanfattning : Hundreds of loci have been robustly associated with circulating lipids, atherosclerosis and coronary artery disease; but for most loci the causal genes and mechanisms remain uncharacterized. The overall aim of my thesis is to develop and validate novel in vivo model systems that are suitable for high-throughput, image-based genetic screens in coronary artery disease and related traits, and use these model systems to systematically characterize positional candidate genes. LÄS MER
5. Contributions to management and validation of non-functional requirements
Sammanfattning : Non-functional requirements (NFRs) are essential when considering software quality in that they shall represent the right quality of the intended software. It is generally hard to get hold of NFRs and to specify them in measurable terms, and most software development methods applied today focus on functional requirements (FRs). LÄS MER