Sökning: "functional genomics"
Visar resultat 1 - 5 av 103 avhandlingar innehållade orden functional genomics.
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Sammanfattning : Natural selection will act on a given phenotype to maximize fitness in a particular environment, even if this would result in reduced fitness in other environments. In insects some of the strongest selection pressures act on timing life cycles to seasonal variation in environmental conditions, in order to maximize growth, reproduction, and to anticipate the onset of winter. LÄS MER
Sammanfattning : Functional genomics has become an important and established research discipline during the last 10 years, mainly as a consequence of the completion of large-scale genome sequencing projects. The human genome is now predicted to transcribe 20,000 25,000 protein coding genes, which is only a quarter of the number suggested a few years ago. LÄS MER
Sammanfattning : The complex disease investigations presented in this thesis aimed to provide new information regarding underlying genetics by using targeted sequencing and ethnically homogeneous cohorts. This work moved past current methodologies and addressed data stratification issues, that might have been hindering new findings. LÄS MER
5. Cold Acclimation : Dissecting the plant low temperature signaling pathway using functional genomics
Sammanfattning : The physiological process of cold acclimation protects plants native to the temperate regions of the world from the deleterious effects of low and freezing temperatures. This is achieved by a series of transcriptional, regulatory, and metabolic changes that enable continued growth and survival. Within minutes of exposure to temperatures below ca. LÄS MER