Sökning: "functional genomics"

Visar resultat 1 - 5 av 103 avhandlingar innehållade orden functional genomics.

  1. 1. Functional proteomics : Generation and analysis of cDNA-encoded proteins

    Författare :Susanne Gräslund; KTH; []
    Nyckelord :functional genomics; functional proteomics; gene characterization; E. coli expression; affinity purification; immunolocalization; mouse testis; spermatogenesis; rabbit antibodies; affibody; tektin; Anaphase-promoting complex or cyclosome.;

    Sammanfattning : .... LÄS MER

  2. 2. Functional genomics of diapause in two temperate butterflies

    Författare :Peter Pruisscher; Karl Gotthard; Dieter Ebert; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; diapause induction; adaptation; genomics; transcriptomics; populationsgenetik; Population Genetics;

    Sammanfattning : Natural selection will act on a given phenotype to maximize fitness in a particular environment, even if this would result in reduced fitness in other environments. In insects some of the strongest selection pressures act on timing life cycles to seasonal variation in environmental conditions, in order to maximize growth, reproduction, and to anticipate the onset of winter. LÄS MER

  3. 3. Functional genomics studies of PINK1

    Författare :Camilla Scheele; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Functional genomics has become an important and established research discipline during the last 10 years, mainly as a consequence of the completion of large-scale genome sequencing projects. The human genome is now predicted to transcribe 20,000 25,000 protein coding genes, which is only a quarter of the number suggested a few years ago. LÄS MER

  4. 4. Complex disease genetics : Utilising targeted sequencing and homogeneous ancestry

    Författare :Argyri Mathioudaki; Kerstin Lindblad-Toh; Panagiotis Deloukas; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; ankylosing spondylitis; breast cancer; targeted sequencing; Sweden; genetics; population stratification.; Molekylär genetik; Molecular Genetics;

    Sammanfattning : The complex disease investigations presented in this thesis aimed to provide new information regarding underlying genetics by using targeted sequencing and ethnically homogeneous cohorts. This work moved past current methodologies and addressed data stratification issues, that might have been hindering new findings. LÄS MER

  5. 5. Cold Acclimation : Dissecting the plant low temperature signaling pathway using functional genomics

    Författare :Catherine Benedict; Vaughan Hurry; Matsuo Uemura; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; cold acclimation; functional genomics; microarray; Populus tremula; Arabidopsis thaliana; gene voting; regulon; enhancer-blocking; Plant physiology; Växtfysiologi;

    Sammanfattning : The physiological process of cold acclimation protects plants native to the temperate regions of the world from the deleterious effects of low and freezing temperatures. This is achieved by a series of transcriptional, regulatory, and metabolic changes that enable continued growth and survival. Within minutes of exposure to temperatures below ca. LÄS MER