Sökning: "Genetisk och molekylär epidemiologi"
Visar resultat 1 - 5 av 10 avhandlingar innehållade orden Genetisk och molekylär epidemiologi.
1. Genetic and phenotypic discordance in cardiometabolic diseases
Sammanfattning : Cardiometabolic conditions such as obesity and type 2 diabetes (T2D) are among the first causes of death globally, and the number of people affected is rapidly increasing. Both conditions are intricately connected and are associated with many life-threatening cardiovascular disease (CVD). LÄS MER
2. Functional genomics approaches to dissect causal DNA variations in obesity and type 2 diabetes
Sammanfattning : GWAS studies have identified hundreds of loci that associate with obesity and type 2 diabetes. However, the functional relevance of the genetic variants, and their impact on disease or traits, is largely unknown. LÄS MER
3. Use of data mining and artificial intelligence to derive public health evidence from large datasets
Sammanfattning : This thesis explores the use of data mining and AI-tailored frameworks for extracting public health evidence from large health datasets. The research presented in this thesis demonstrates the potential of these tools for automating and simplifying the data mining process, and for providing valuable insights into various public health issues. LÄS MER
4. Elucidating causal relationships between energy homeostasis and cardiometabolic outcomes
Sammanfattning : Energy metabolism dyshomeostasis is associated with multiple health problems. For example, abundant epidemiological data show that obesity and overweight increase the risk of cardiometabolic diseases and early mortality. LÄS MER
5. Genetic and Environmental Risk Factors in the Development of Obesity
Sammanfattning : Lifestyle behaviors and genetic variation have clear and distinguishable effects on obesity risk; however, the pattern of disease occurrence within and between populations that differ in their genetic and environmental underpinnings suggests obesity is caused in part by the interaction between adverse lifestyle behaviors and the genetic risk profile of an individual. This thesis aims to investigate the joint effects of genetic and environmental (specifically lifestyle) risk factors for obesity and its comorbidities using cross-sectional and longitudinal epidemiological cohorts and clinical trials. LÄS MER