Sökning: "precision medicine"

Visar resultat 1 - 5 av 247 avhandlingar innehållade orden precision medicine.

1. 1. New targeted therapies for malignant neural tumors : From systematic discovery to zebrafish models

   Författare :Elin Almstedt; Sven Nelander; Rogier Versteeg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuroblastoma; glioblastoma; data integration; zebrafish models; precision medicine; Oncology; Onkologi; Medical Cell Biology; Medicinsk cellbiologi; Medical Informatics; Medicinsk informatik; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy; Molekylär medicin; Molecular Medicine;

   Sammanfattning : Cancers in the neural system presents a major health challenge. The most aggressive brain tumor in adults, glioblastoma, has a median survival of 15 months and few therapeutic options. High-risk neuroblastoma, a childhood tumor originating in the sympathetic nervous system, has a 5-year survival under 50%, despite extensive therapy. LÄS MER

3. 2. Preventing Cardiovascular Disease. Complementary precision medicine

   Författare :Martiné Wlosinska; Thoraxkirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Aged garlic extract; CAC; Placebo-controlled; Double-blinded; Blood pressure; Data science; Predictive models;

   Sammanfattning : AbstractBackground: Non-communicable diseases are the number one killer worldwide and the leading one,cardiovascular disease (CVD), is responsible for more than 30% of all deaths. CVD is a progressive disease whichalso makes it economical, easy and effective to prevent. LÄS MER

4. 3. In Vivo Accuracy and Precision in Prosthodontics

   Författare :Robert Nedelcu; Andreas Thor; Ingela Nyström; Pontus Olsson; Per Vult von Steyern; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; accuracy; precision; in vivo; digital impression; intraoral scanner; polyether impression; implant impression; framework misfit; fully edentulous; Oral and Maxillofacial Surgery; Käkkirurgi; Oral and Maxillofacial Surgery; Käkkirurgi;

   Sammanfattning : Background: There has been a dramatic increase in commercially available intraoral scanners (IOS) in the last decade, offering to replace indirect digitization of models (MOD) fabricated from impressions (IMPR). IOS has benefits of less patient discomfort and a faster workflow to fabricate fixed dental prosthesis (FDP), and implant-supported prostheses (IFD). LÄS MER

5. 4. The genetics of schizophrenia : sex, drugs, and cognition

   Författare :Elise Koch; Karolina Kauppi; Lars Nyberg; Anders Lundquist; Alessandro Serretti; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; schizophrenia; genetics; cognition; sex differences; polygenic risk; fMRI; network medicine; drug repurposing; precision medicine;

   Sammanfattning : Cognitive impairment constitutes an important predictor of general functional outcomes in schizophrenia. Polygenic risk for schizophrenia has been linked to cognitive ability as well as brain activation during cognitive processing. LÄS MER

7. 5. Targeting molecular mechanisms for epigenetic silencing in multiple myeloma : Implications for biology and precision medicine

   Författare :Patrick Nylund; Helena Jernberg Wiklund; Antonia Kalushkova Nair; Fredrik Öberg; Toril Holien; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple myeloma; epigenetics; PRC2; lncRNA; metabolomics; miRNA.;

   Sammanfattning : Multiple myeloma (MM) is a heterogeneous haematological cancer where malignant plasma cells clonally expand within the bone marrow. The transcriptional repressor PRC2 and its catalytic subunit EZH2 play a major role in MM, as PRC2 re-targeting results in a MM-specific gene silencing profile. LÄS MER