Sökning: "HLA typing"

Visar resultat 1 - 5 av 20 avhandlingar innehållade orden HLA typing.

  1. 1. Multiplex HLA-DR-DQ genotyping : for genetic epidemiology and clinical risk assessment

    Författare :Ewa Lavant; Malmö högskola; []
    Nyckelord :HLA-DRB1; HLA-DQB1; HLA-DQA1; PCR-SSP; type 1 diabetes; celiac disease; autoimmune disease; capillary gel electrophoresis; genotyping;

    Sammanfattning : The human leukocyte antigens (HLA) are highly polymorphic cell surface proteins encoded in the major histocompatibility complex (MHC) region on chromosome 6. The HLA system has been well known as transplantation antigens but the primary biological role of the HLA molecules is regulation of immune response by presenting peptide fragments to T-lymphocytes. LÄS MER

  3. 2. Human leukocyte antigen in sickness and in health : Ankylosing spondylitis and HLA in Sweden

    Författare :Jessika Nordin; Kerstin Lindblad-Toh; Jennifer Meadows; Matthew Webster; Alison Meynert; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Disease genetics; Ankylosing spondylitis; HLA typing; Imputation; Inference; Sex-stratified; HLA-B*27 independent; Association tests; Functional validation; Bioinformatics; Bioinformatik; Molekylär genetik; Molecular Genetics;

    Sammanfattning : The human leukocyte antigen (HLA) plays a major role in keeping us healthy, but some of the HLA alleles can contribute to disease susceptibility. One example is HLA-B*27, which confers increased susceptibility of ankylosing spondylitis and represents one of the strongest genetic associations found in any common human disease. LÄS MER

  4. 3. Genetic typing of HLA polymorphism : application to studies of disease association and forensic medicine

    Författare :Marie Allen; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  5. 4. Tapasin - The star of the show in HLA-I maturation

    Författare :Camilla Thuring; Antigen presentation; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tapasin; HLA-I; tumor; antigen presentation;

    Sammanfattning : Human leukocyte antigen class I (HLA-I) molecules are present on the cell surface of all nucleated cells. They bind intracellular peptides and present them to the immune system thus providing a readout to cytotoxic T-cells about the status of a cell. LÄS MER

  7. 5. HLA polymorphism : genomic typing and impact on unrelated stem cell transplantation

    Författare :Anna Aldener-Cannavá; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The HLA (Human Leukocyte Antigen) region is the most polymorphic in the human genome. The extended polymorphism contributes to the ability both of individuals and populations to combat diversity in the pathogens to which they are exposed. LÄS MER